#ppiposseofpicks: 125-158 (.442)
#ppiupsetalert: 36-47 (.434)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN2 | TCU | #3 Kansas | -8.5 | -8 | |
| 12 PM | ACCN | #8 Florida State | Miami (FL) | 14 | 15 | |
| 12 PM | ESPN | #11 Auburn | #18 LSU | 5 | 7 | |
| 12 PM | FOX | Michigan | #16 Michigan State | 2 | -2 | #ppiupsetalert, Michigan +118 |
| 1 PM | CBS | Tennessee | #15 Kentucky | -2 | -2 | #ppiupsetalert, Tennessee +2 |
| 2 PM | CBSSN | #6 Dayton | Saint Louis | 12.5 | 12 | |
| 2 PM | ESPNU | Oklahoma | #13 West Virginia | -2.5 | -2 | #ppiupsetalert, Oklahoma +2.5 |
| 2:30 PM | FOX | #10 Villanova | #12 Seton Hall | 3.5 | 1 | #ppiupsetalert, Seton Hall +3.5 |
| 4 PM | ESPN | #5 Louisville | Virginia | 7 | 13 | Louisville -7 |
| 4 PM | BTN | #22 Penn State | Minnesota | 7 | 8 | |
| 6 PM | ESPN2 | #1 Baylor | Oklahoma State | 12 | 17 | Baylor -12 |
| 6 PM | ESPN | North Carolina | Duke | -7.5 | -9 | |
| 6 PM | BTN | #17 Iowa | Nebraska | 14.5 | 19 | Iowa -14.5 |
| 6 PM | CBSSN | #21 Creighton | St. John’s | 9.5 | 13 | |
| 6 PM | PAC12 | #24 Colorado | Stanford | 9 | 10 | |
| 8 PM | CBSSN | Air Force | #4 San Diego State | -12.5 | -18 | San Diego State -12.5 |
| 10 PM | ESPN | Saint Mary’s | #1 Gonzaga | -6 | -1 | #ppiupsetalert, Saint Mary’s +6 |
| 10 PM | ESPN2 | #23 Arizona | UCLA | 12.5 | 13 | |
| 10:30 PM | PAC12 | Oregon State | Oregon | -3 | -7 | |
| 12 PM | CBSSN | George Washington | Rhode Island | -9.5 | -9 | |
| 2 PM | ESPN+ | Fordham | Richmond | -10.5 | -10 | |
| 3 PM | NBCSN | Duquesne | St. Bonaventure | 4 | 6 | |
| 5 PM | NBCSN | La Salle | Saint Joseph’s | 8 | 11 | |
| 12 PM | ACCNX | Virginia Tech | Boston College | 7 | 6 | |
| 2 PM | ACCNX | Pittsburgh | Georgia Tech | 2.5 | 4 | |
| 8 PM | CAN | Syracuse | Wake Forest | 8.5 | 10 | |
| 12 PM | ESPNU | Temple | SMU | -2 | -3 | |
| 4 PM | CBSSN | Memphis | South Florida | 8.5 | 11 | |
| 6 PM | ESPNU | Tulane | East Carolina | 6 | 7 | |
| 4 PM | ESPN2 | Texas | Texas Tech | -2.5 | 3 | Texas +125 |
| 8 PM | ESPN2 | Iowa State | Kansas State | 4.5 | 5 | |
| 12 PM | Georgetown | DePaul | 4.5 | 7 | ||
| 8 PM | FS1 | Xavier | Providence | 4 | 7 | |
| 5:05 PM | Eastern Washington | Montana State | 7 | 11 | ||
| 2 PM | ESPN | Indiana | Purdue | 3 | 1 | |
| 4:30 PM | ESPN3 | Western Michigan | Ball State | -5 | -2 | |
| 8 PM | PAC12 | Utah | California | 8.5 | 7 | |
| 10 PM | Arizona State | USC | 3.5 | 2 | ||
| 1 PM | SECN | South Carolina | Texas A&M | 8 | 4 | |
| 2 PM | ESPN2 | Ole Miss | Florida | -3 | -2 | |
| 3:30 PM | SECN | Missouri | Arkansas | -1 | -5 | |
| 6 PM | SECN | Georgia | Alabama | 1 | -2 | |
| 8:30 PM | SECN | Mississippi State | Vanderbilt | 16 | 14 |