#ppiupsetalertrecord 59-36 (62.1%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | FS1 | Seton Hall | #23 Creighton | -3.5 | 1 | #ppiupsetalert, Seton Hall +130 |
| 7 PM | SECN | Vanderbilt | #6 Tennessee | -10.5 | -8 | |
| 7 PM | ESPN2 | West Virginia | #11 Iowa State | 3.5 | 2 | #ppiupsetalert, West Virginia -184 |
| 8 PM | ESPN+ | #2 Houston | Tulsa | 28.5 | 29 | |
| 8 PM | CBSSN | #20 Providence | Georgetown | 12.5 | 21 | Providence -12.5 |
| 9 PM | ESPN2 | #3 Alabama | Florida | 9.5 | 17 | Alabama -9.5 |
| 9 PM | ESPNU | #14 Baylor | Oklahoma | 9.5 | 9 | |
| 10 PM | CBSSN | Utah State | #25 San Diego State | 2.5 | 1 | #ppiupsetalert, Utah State -137 |
| 6:30 PM | BTN | Michigan | Nebraska | 11.5 | 10 | |
| 7 PM | ESPNU | Florida State | Syracuse | -3.5 | -4 | |
| 7 PM | ACCNX | Georgia Tech | Notre Dame | -1.5 | 4 | Georgia Tech -104 |
| 7 PM | ACCN | Virginia Tech | Boston College | 12.5 | 10 | |
| 8 PM | ESPN+ | Oklahoma State | Texas Tech | 5.5 | 6 | |
| 8:30 PM | FS1 | Villanova | DePaul | 9.5 | 8 | |
| 8:30 PM | BTN | Penn State | Wisconsin | 3.5 | 4 | |
| 9 PM | SECN | Mississippi State | LSU | 9.5 | 8 | |
| 10:30 PM | FS1 | Wyoming | Utah | -3.5 | -5 |