#ppiupsetalert record: 28-21 (.571)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN | Oklahoma | #4 Tennessee | -5.5 | -5 | |
| 12 PM | ESPN+ | #8 Iowa State | TCU | 16.5 | 16 | |
| 12 PM | FOX | #9 Michigan State | Oregon | 8.5 | 4 | #ppiupsetalert, Oregon +315 |
| 12 PM | ESPN2 | #14 Kentucky | South Carolina | 10.5 | 10 | |
| 12 PM | USA | Davidson | Richmond | 6.5 | 14 | Davidson -6.5 |
| 12 PM | FS1 | Georgetown | Seton Hall | 7.5 | 15 | Georgetown -10.5 |
| 1 PM | NBC | Iowa | #21 Wisconsin | -5.5 | -9 | Wisconsin -5.5 |
| 1 PM | CBS | Indiana | #24 Michigan | -3.5 | -3 | #ppiupsetalert, Indiana +146 |
| 1 PM | CW | Notre Dame | Virginia Tech | 7.5 | 3 | Virginia Tech +7.5 |
| 2 PM | ESPN | Kansas State | #16 Kansas | -4.5 | -6 | |
| 2 PM | ESPN+ | Ball State | Southern Miss | 2.5 | 3 | |
| 2 PM | ESPN+ | Baylor | UCF | 10.5 | 4 | UCF +10.5 |
| 2 PM | ESPN2 | Louisville | Miami (FL) | 17.5 | 21 | Louisville -17.5 |
| 2 PM | ESPN+ | Southern Illinois | UIC | 1.5 | -2 | UIC -110 |
| 3 PM | Peacock | Butler | Providence | 4.5 | 7 | |
| 3:15 PM | CW | Syracuse | Boston College | 7.5 | 8 | |
| 3:30 PM | SECN | #15 Missouri | #10 Texas A&M | 4.5 | 0 | #ppiupsetalert, Missouri -188 |
| 4 PM | ESPN2 | #1 Auburn | #6 Florida | 9.5 | 9 | |
| 4 PM | ESPN+ | Colorado | #5 Houston | -13.5 | -6 | Colorado +13.5 |
| 4 PM | ESPNU | North Carolina | Pittsburgh | 5.5 | 2 | Pittsburgh +5.5 |
| 4 PM | ESPN+ | George Mason | Rhode Island | 8.5 | 10 | |
| 4 PM | ESPN+ | Valparaiso | Murray State | -2.5 | -1 | |
| 4 PM | Wyoming | UNLV | -2.5 | -1 | ||
| 4 PM | Air Force | New Mexico | -15.5 | -23 | New Mexico -15.5 | |
| 4 PM | BTN | UCLA | Penn State | 10.5 | 13 | |
| 4 PM | ESPNN | Liberty | Sam Houston State | 10.5 | 14 | Liberty -10.5 |
| 5 PM | ESPN+ | West Virginia | Utah | 7.5 | 5 | |
| 5 PM | ACCN | California | Wake Forest | -2.5 | -6 | Wake Forest -2.5 |
| 5 PM | ESPN+ | Belmont | Missouri State | 7.5 | 15 | Belmont -7.5 |
| 5 PM | ESPN+ | Kennesaw State | Middle Tennessee | 2.5 | -1 | Middle Tennessee +124 |
| 5 PM | ESPN+ | Jacksonville State | Western Kentucky | 3.5 | 7 | Jacksonville State -3.5 |
| 5:30 PM | CW | Virginia | Georgia Tech | 2.5 | 6 | Virginia -2.5 |
| 6 PM | SECN | Georgia | #22 Mississippi State | 1.5 | 1 | #ppiupsetalert, Georgia -125 |
| 6 PM | BTN | Minnesota | #23 Illinois | -6.5 | 0 | #ppiupsetalert, Minnesota +215 |
| 6 PM | ESPN2 | Cincinnati | BYU | 1.5 | 0 | |
| 6 PM | CBSSN | Duquesne | Loyola (CHI) | -1.5 | -2 | |
| 6 PM | ESPN+ | Drake | Indiana State | 12.5 | 16 | Drake -12.5 |
| 6 PM | ESPNU | Northern Iowa | Illinois State | 5.5 | 5 | |
| 6 PM | ESPN+ | Washington State | Pepperdine | 10.5 | 13 | |
| 6:30 PM | ESPN | Clemson | #2 Duke | -6.5 | -1 | #ppiupsetalert, Clemson +210 |
| 7 PM | ACCN | Stanford | NC State | 6.5 | 11 | Stanford -6.5 |
| 7 PM | ESPN+ | Santa Clara | San Diego | 19.5 | 27 | Santa Clara -19.5 |
| 8 PM | CBSSN | Evansville | Bradley | -4.5 | -9 | Bradley -4.5 |
| 8 PM | ESPN+ | Pacific | Gonzaga | -25.5 | -17 | Pacific +25.5 |
| 8:30 PM | ESPN | Arkansas | #3 Alabama | -5.5 | -9 | Alabama -5.5 |
| 8:30 PM | SECN | LSU | #25 Ole Miss | -5.5 | -6 | |
| 9 PM | ESPN+ | Loyola Marymount | San Francisco | -3.5 | -2 | |
| 9 PM | ESPN+ | New Mexico State | UTEP | 1.5 | 2 | |
| 10 PM | CBSSN | Colorado State | San Diego State | 2.5 | 2 | |
| 10 PM | ESPN2 | Oregon State | Saint Mary’s | -4.5 | -3 | |
| 10:30 PM | ESPN | #20 Arizona | #13 Texas Tech | 3.5 | 2 | #ppiupsetalert, Arizona -164 |
| 10:30 PM | BTN | Washington | Northwestern | 3.5 | 8 | Washington -3.5 |