#ppiposseofpicks: 78-97 (.455)
#ppiupsetalert: 18-19 (.486)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPNN | #5 Auburn | Georgia | 11 | 13 | |
| 12 PM | FOX | Indiana | #11 Ohio State | -2.5 | 2 | #ppiupsetalert, Indiana +115 |
| 12 PM | ESPN | #14 Kentucky | Alabama | 8.5 | 5 | #ppiupsetalert, Alabama +5 |
| 12 PM | FS1 | #16 Villanova | Georgetown | 7.5 | 4 | #ppiupsetalert, Georgetown +7.5 |
| 12:30 PM | NBCSN | #15 Dayton | Massachusetts | 19 | 20 | |
| 1 PM | CBS | #3 Kansas | #4 Baylor | 7.5 | 7 | |
| 2 PM | ESPN | Notre Dame | #13 Louisville | -3.5 | -1 | #ppiupsetalert, Notre Dame +155 |
| 2:15 PM | BTN | #20 Penn State | Wisconsin | 4 | 8 | |
| 4 PM | Loyola Marymount | #1 Gonzaga | -18.5 | -22 | ||
| 4 PM | ESPN | #18 Virginia | Syracuse | 7.5 | 8 | |
| 6 PM | ESPN | #17 West Virginia | #22 Texas Tech | 4.5 | 14 | West Virginia -4.5 |
| 8 PM | ACCN | #2 Duke | Wake Forest | 19 | 19 | |
| 10 PM | ESPN3 | #7 San Diego State | Boise State | 11 | 18 | San Diego State -11 |
| 10:30 PM | PAC12 | #9 Oregon | Arizona State | 10.5 | 11 | |
| 2 PM | CBSSN | VCU | Rhode Island | 8.5 | 11 | |
| 2 PM | ESPN+ | St. Bonaventure | Fordham | 12.5 | 13 | |
| 2 PM | ESPN+ | La Salle | George Mason | 3.5 | 2 | |
| 2:30 PM | NBCSN | Davidson | Saint Joseph’s | 15 | 12 | |
| 4 PM | ESPN+ | George Washington | Duquesne | -7 | -13 | Duquesne -7 |
| 6 PM | ESPN+ | Richmond | Saint Louis | 6 | 3 | |
| 2 PM | ACCNX | Virginia Tech | NC State | 2 | 2 | |
| 4:30 PM | ACCNX | North Carolina | Clemson | 4.5 | 7 | |
| 6 PM | ACCN | Boston College | Georgia Tech | -3.5 | 3 | Boston College +155 |
| 12 PM | ESPN2 | UCF | Cincinnati | -2.5 | 1 | |
| 12 PM | ESPNU | Temple | Tulane | 9.5 | 7 | |
| 2 PM | ESPNU | East Carolina | SMU | -8 | -12 | |
| 4 PM | ESPN2 | Tulsa | Houston | -6.5 | -6 | |
| 2 PM | ESPN2 | TCU | Oklahoma State | 3.5 | 7 | |
| 8 PM | ESPN2 | Iowa State | Oklahoma | 2.5 | -4 | Oklahoma +125 |
| 8 PM | LHN | Texas | Kansas State | 4.5 | 9 | |
| 12 PM | St. John’s | DePaul | 3.5 | -1 | ||
| 2 PM | FOX | Xavier | Creighton | 3.5 | 6 | |
| 4 PM | CBSSN | Seton Hall | Marquette | 6 | 11 | Seton Hall -6 |
| 12 PM | BTN | Illinois | Rutgers | 5.5 | 5 | |
| 4:30 PM | BTN | Northwestern | Nebraska | 5.5 | 4 | |
| 8 PM | Montana State | Portland State | 1 | 10 | Montana State -1 | |
| 6 PM | PAC12 | Stanford | Washington State | 10 | 15 | Stanford -10 |
| 8 PM | PAC12 | California | Washington | -6.5 | -4 | |
| 10 PM | ESPN2 | UCLA | USC | -1 | -6 | USC -1 |
| 1 PM | SECN | Tennessee | South Carolina | 6.5 | 11 | |
| 3:30 PM | SECN | Vanderbilt | Texas A&M | 5.5 | 3 | |
| 6 PM | SECN | Ole Miss | Arkansas | -2 | -7 | Arkansas -2 |
| 8 PM | ESPN | LSU | Mississippi State | 8 | 8 | |
| 8:30 PM | SECN | Missouri | Florida | -3 | -1 |