#ppiupsetalerecord: 13-18 (41.9%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 5 PM | ESPN2 | Stanford | #5 USC | -5 | -7 | |
| 6:30 PM | SECN | #22 Tennessee | South Carolina | 13.5 | 7 | South Carolina +13.5 |
| 6:30 PM | BTN | Penn State | Rutgers | 3 | 5 | |
| 7 PM | ESPN3 | Akron | Ball State | 9 | 9 | |
| 7 PM | ESPN2 | #1 Baylor | #19 Texas Tech | 12 | 16 | Baylor -12 |
| 7 PM | ESPN | Vanderbilt | #18 Kentucky | -6.5 | 1 | #ppiupsetalert, Vanderbilt +220 |
| 7 PM | FS1 | Marquette | DePaul | 7 | 9 | |
| 7 PM | ESPNU | Syracuse | Pittsburgh | 10.5 | 12 | |
| 8 PM | ESPN+ | #9 Kansas | #15 Iowa State | 12 | 7 | Iowa State +12 |
| 8 PM | ACCN | Florida State | Miami (FL) | 6 | -1 | Miami (FL) +198 |
| 8:30 PM | LHN | #21 Texas | Oklahoma | 6.5 | 0 | #ppiupsetalert, Oklahoma +225 |
| 8:30 PM | BTN | Nebraska | #25 Illinois | -13.5 | -11 | |
| 8:30 PM | SECN | Texas A&M | Ole Miss | 4 | 7 | |
| 9 PM | ESPN | #24 Alabama | #4 Auburn | 1.5 | -5 | Auburn +102 |
| 9 PM | FS1 | Creighton | #23 Providence | 4 | -4 | #ppiupsetalert, Creighton -182 |
| 9 PM | ESPN2 | West Virginia | Oklahoma State | 4 | 9 | West Virginia -4 |
| 10 PM | Fresno State | San Jose State | 15.5 | 10 | San Jose State +15.5 | |
| 11 PM | CBSSN | UNLV | New Mexico | 6 | 9 |