#ppiupsetalert record: 9-6 (.600)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN | #4 Duke | Notre Dame | 19.5 | 23 | Duke -19.5 |
| 12 PM | BTN | #13 Illinois | USC | 13.5 | 4 | #ppiupsetalert, USC +13.5 |
| 12 PM | ESPN2 | Pittsburgh | Louisville | 3.5 | 6 | |
| 12 PM | ESPN+ | St. Bonaventure | La Salle | 11.5 | 13 | |
| 12 PM | FOX | Butler | Creighton | -2.5 | 1 | Butler +126 |
| 1 PM | SECN | South Carolina | #2 Auburn | -16.5 | -15 | |
| 1 PM | ESPN+ | Indiana State | Belmont | 2.5 | -2 | Belmont +116 |
| 1 PM | CBS | New Mexico | San Diego State | 4.5 | 5 | |
| 1 PM | Monmouth | Charleston | -7.5 | -16 | Charleston -7.5 | |
| 1 PM | ESPN+ | New Hampshire | Binghamton | 0 | -10 | Binghamton -4.5 |
| 1 PM | Lafayette | Holy Cross | 5.5 | -5 | Holy Cross +205 | |
| 2 PM | ESPN | Texas Tech | #3 Iowa State | 2.5 | -3 | #ppiupsetalert, Texas Tech -134 |
| 2 PM | FOX | Georgetown | #9 Connecticut | -4.5 | -2 | #ppiupsetalert, Georgetown +185 |
| 2 PM | ESPN+ | Cincinnati | #11 Kansas | 1.5 | -6 | Kansas -110 |
| 2 PM | ESPN+ | #19 Memphis | East Carolina | 12.5 | 26 | Memphis -12.5 |
| 2 PM | ESPN2 | TCU | BYU | -2.5 | -4 | |
| 2 PM | ACCN | Clemson | Florida State | 8.5 | 3 | Florida State +8.5 |
| 2 PM | ESPN+ | George Mason | Massachusetts | 11.5 | 17 | George Mason -11.5 |
| 2 PM | ESPN+ | Davidson | Fordham | 8.5 | 11 | |
| 3 PM | CW | Boston College | Syracuse | 1.5 | 5 | Boston College -1.5 |
| 3 PM | CBSSN | Saint Joseph’s | Loyola (CHI) | 5.5 | 7 | |
| 3 PM | ESPN+ | UIC | Bradley | -2.5 | 1 | UIC +128 |
| 3 PM | Air Force | San Jose State | -2.5 | -5 | ||
| 3 PM | ESPN+ | Western Kentucky | Kennesaw State | 8.5 | 3 | Kennesaw State +8.5 |
| 3:30 PM | SECN | Missouri | Vanderbilt | 4.5 | -1 | Vanderbilt +172 |
| 3:30 PM | ESPN+ | Sam Houston State | Florida International | 8.5 | 11 | |
| 4 PM | ESPN | Arkansas | #8 Florida | -4.5 | -9 | Florida -4.5 |
| 4 PM | Colorado State | UNLV | 5.5 | 7 | ||
| 4 PM | ESPN2 | SMU | Georgia Tech | 10.5 | 17 | SMU -10.5 |
| 4 PM | ESPNU | Stanford | Virginia | 7.5 | 8 | |
| 4 PM | ACCN | NC State | North Carolina | -4.5 | -3 | |
| 4 PM | ESPN+ | Murray State | Valparaiso | 7.5 | 7 | |
| 4 PM | FS1 | DePaul | Xavier | -5.5 | 3 | DePaul +172 |
| 5 PM | CBSSN | Providence | Seton Hall | 8.5 | 7 | |
| 5:15 PM | CW | Miami (FL) | Wake Forest | -4.5 | -12 | Wake Forest -4.5 |
| 6 PM | ESPN | Texas | #1 Tennessee | -4.5 | -9 | Tennessee -4.5 |
| 6 PM | ESPN+ | Kansas State | #12 Houston | -10.5 | -10 | |
| 6 PM | ESPN2 | Georgia | #17 Oklahoma | 6.5 | 4 | #ppiupsetalert, Georgia -275 |
| 6 PM | SECN | #23 Ole Miss | LSU | 9.5 | 10 | |
| 6 PM | ACCN | California | Virginia Tech | 7.5 | 10 | |
| 6 PM | ESPN+ | Richmond | Rhode Island | -2.5 | -1 | |
| 6 PM | ESPN+ | Drake | Evansville | 14.5 | 20 | Drake -14.5 |
| 6 PM | ESPN+ | Middle Tennessee | Jacksonville State | 5.5 | 13 | Middle Tennessee -5.5 |
| 7 PM | ESPN+ | Utah | Oklahoma State | 7.5 | -2 | Oklahoma State +245 |
| 7 PM | ESPN+ | Southern Illinois | Missouri State | 1.5 | -2 | Missouri State +112 |
| 7 PM | ESPN+ | Illinois State | Northern Iowa | 1.5 | 3 | |
| 7 PM | Fresno State | Nevada | -6.5 | -8 | Fresno State +12.5 | |
| 7 PM | CBSSN | St. John’s | Villanova | 7.5 | 12 | St. John’s -6.5 |
| 7 PM | ESPN+ | Santa Clara | San Francisco | 2.5 | 3 | |
| 8 PM | ESPN | #10 Texas A&M | #5 Alabama | -4.5 | -8 | Alabama -3.5 |
| 8 PM | FOX | Iowa | Indiana | 9.5 | 1 | Indiana +4.5 |
| 8 PM | ESPN+ | Montana State | Northern Arizona | -3.5 | 3 | |
| 8 PM | ESPNU | Louisiana Tech | Liberty | -1.5 | 1 | |
| 8:30 PM | SECN | #14 Mississippi State | #6 Kentucky | 5.5 | 11 | #ppiupsetalert, Mississippi State -220 |
| 9 PM | ESPN | #18 Gonzaga | Washington State | 17.5 | 13 | Washington State +17.5 |
| 9 PM | CBSSN | #25 Utah State | Boise State | 4.5 | 12 | Utah State -4.5 |
| 9 PM | ESPN+ | UTEP | New Mexico State | 7.5 | 8 | UTEP – |
| 9:30 PM | ESPN+ | Arizona State | Baylor | -5.5 | 1 | Arizona State +190 |
| 10 PM | ESPN | Arizona | UCF | 16.5 | 1 | UCF +16.5 |
| 10 PM | ESPN+ | San Diego | Saint Mary’s | -16.5 | -22 | Saint Mary’s -16.5 |
| 10 PM | ESPN+ | Pacific | Oregon State | -8.5 | -15 | Oregon State -8.5 |