#ppiupsetalert record: 4-18 (.181)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN | #7 Michigan | #9 Wisconsin | 3.5 | 9 | Michigan -3.5 |
| 7 PM | ESPN2 | Vanderbilt | #10 Tennessee | -12 | -10 | |
| 7 PM | #20 Virginia Tech | #19 Duke | 1.5 | 9 | Virginia Tech -1.5 | |
| 8 PM | ESPN+ | Oklahoma State | #6 Kansas | -4 | -1 | Oklahoma State +155, #ppiupsetalert |
| 7:30 PM | ESPN+ | Oklahoma | TCU | 7.5 | 0 | TCU +285 |
| 7 PM | SECN | Florida | Ole Miss | 3.5 | 7 | Florida -3.5 |
| 9 PM | ESPN | Kentucky | Alabama | 2 | -7 | Alabama +115 |
| 7 PM | FS1 | St. John’s | Butler | 2 | 9 | St. John’s -2 |
| 9 PM | FS1 | Marquette | Providence | 3 | 1 | |
| 7 PM | ACCNX | Boston College | Miami (FL) | -2.5 | 1 | Boston College +120 |
| 9 PM | ACCN | North Carolina | Syracuse | 3.5 | 8 | North Carolina -3.5 |
| 7 PM | Bowling Green | Ball State | 7.5 | 11 | Bowling Green -7.5 |