#ppiposseofpicks: 90-104 (.464)
#ppiupsetalert: 21-23 (.477)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | FS1 | #21 Ohio State | Nebraska | 17.5 | 17 | |
| 7 PM | ESPN | Clemson | #3 Duke | -11 | -11 | |
| 7 PM | ACCN | Pittsburgh | #11 Louisville | -6 | -3 | #ppiupsetalert, Pittsburgh +180 |
| 8 PM | CBSSN | #13 Dayton | VCU | 8 | 11 | |
| 8 PM | ESPN+ | Kansas State | #23 Texas Tech | -3.5 | -1 | #ppiupsetalert, Kansas St +155 |
| 8:30 PM | FS1 | #14 Villanova | DePaul | 10.5 | 8 | |
| 9 PM | ESPN | Oklahoma | #6 Kansas | -6 | -1 | #ppiupsetalert, Oklahoma +230 |
| 9 PM | ESPNU | #12 West Virginia | TCU | 8 | 9 | |
| 9 PM | ESPN2 | Wisconsin | #17 Maryland | 3 | -1 | #ppiupsetalert, Wisconsin -145 |
| 11 PM | ESPN2 | Fresno State | #7 San Diego State | -6.5 | -17 | San Diego St -6.5 |
| 7 PM | ESPNU | Davidson | Richmond | 4 | -2 | Richmond +155 |
| 9 PM | ACCN | Wake Forest | Virginia Tech | -2.5 | 0 | Wake Forest +110 |
| 8 PM | ESPN3 | Tulane | UCF | 1 | 5 | Tulane -1 |
| 8 PM | BTN | Northwestern | Iowa | -5.5 | -8 | |
| 7 PM | ESPN+ | Eastern Michigan | Ball State | -3.5 | 3 | Eastern Michigan +155 |
| 7 PM | ESPN2 | Florida | Ole MIss | 10 | 10 | |
| 7 PM | SECN | Texas A&M | LSU | -6 | -2 | |
| 9 PM | SECN | Mississippi State | Missouri | 4 | 3 |