#ppiupsetrecord: 14-24 (36.8%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | BTN | #10 Michigan State | Northwestern | 7.5 | 19 | Michigan State -7.5 |
| 12 PM | FOX | #17 Xavier | Creighton | 9.5 | 10 | |
| 12 PM | ESPN2 | Kansas State | #19 Texas Tech | -3.5 | -4 | #ppiupsetalert, Kansas State +3.5 |
| 12 PM | FS1 | Marquette | #20 Seton Hall | 1 | 6 | #ppipupsetalert, Marquette -110 |
| 1 PM | ESPN | #18 Kentucky | #22 Tennessee | 5.5 | 4 | #ppiupsetalert, Tennessee +5.5 |
| 1 PM | SECN | South Carolina | Florida | -5 | 4 | South Carolina +176 |
| 1:30 PM | CBS | #9 Kansas | West Virginia | 12 | 8 | West Virginia +12 |
| 2 PM | ESPN3 | #8 Duke | NC State | 14 | 10 | NC State +14 |
| 2 PM | ESPN2 | #12 LSU | Arkansas | 5.5 | 15 | LSU -5.5 |
| 2 PM | ESPN+ | #15 Iowa State | #21 Texas | -3 | 5 | #ppiupsetalert, Texas -154 |
| 2 PM | BTN | Maryland | Rutgers | 5 | 5 | |
| 3 PM | ESPN | Syracuse | Florida State | 2.5 | 1 | |
| 3:30 PM | SECN | Missouri | Texas A&M | -4.5 | -3 | |
| 4 PM | Santa Clara | Gonzaga | -16 | -1 | #ppiupsetalert, Santa Clara +16 | |
| 4 PM | PAC12 | Washington State | California | 9.5 | 8 | |
| 4 PM | ACCN | Pittsburgh | Louisville | -5 | -6 | |
| 4 PM | ESPN2 | TCU | Oklahoma | -1.5 | 2 | |
| 4:30 PM | ACCNX | Virginia | Wake Forest | 3.5 | 1 | |
| 5 PM | ESPN | #1 Baylor | Oklahoma State | 14 | 16 | |
| 5 PM | CBSSN | Air Force | Nevada | -8.5 | 3 | Air Force +290 |
| 5:30 PM | CBSSN | New Mexico | Boise State | -8.5 | -11 | |
| 6 PM | SECN | Mississippi State | #24 Alabama | 1.5 | 0 | |
| 6 PM | PAC12 | Washington | Stanford | 1 | -2 | |
| 6 PM | ACCN | Virginia Tech | Notre Dame | 6.5 | 2 | Notre Dame +6.5 |
| 6 PM | ESPN2 | Georgia | Vanderbilt | -4.5 | -7 | |
| 6 PM | San Jose State | Colorado State | -12 | -7 | ||
| 6:30 PM | ACCNX | Clemson | Boston College | 10.5 | 13 | San Jose +12 |
| 8 PM | PAC12 | #6 Arizona | Utah | 20 | 19 | |
| 8 PM | ESPN2 | Tulsa | #11 Houston | -11.5 | -11 | |
| 8 PM | ACCN | North Carolina | Georgia Tech | 12.5 | 13 | |
| 8:30 PM | SECN | Ole Miss | #4 Auburn | -8.5 | -16 | Auburn -8.5 |
| 9 PM | Utah State | Wyoming | 5.5 | 6 | ||
| 10 PM | ESPN2 | Arizona State | Colorado | -1 | -1 | |
| 10:30 PM | PAC12 | #3 UCLA | Oregon State | 16 | 22 | UCLA -16 |
| 11 PM | FS1 | #5 USC | Oregon | 6.5 | 10 | |
| 11 PM | CBSSN | San Francisco | BYU | 4.5 | 2 |