#ppiposseofpicks: 95-117 (.448)
#ppiupsetalert: 23-28 (.451)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | FS1 | #14 Villanova | Connecticut | 10 | 13 | |
| 12 PM | ESPN2 | Oklahoma State | #2 Baylor | -6 | -7 | |
| 12 PM | FOX | St. John’s | #18 Seton Hall | -5 | -10 | Seton Hall -5 |
| 12 PM | ESPNU | Penn State | #21 Ohio State | 1 | 3 | #ppiupsetalert, Penn St -110 |
| 1 PM | DePaul | #5 Butler | -4 | -7 | ||
| 1 PM | ACCN | Miami (FL) | #9 Florida State | -6 | -5 | |
| 1:30 PM | CBS | Florida | #4 Auburn | 2 | -1 | #ppiupsetalert, Florida -140 |
| 2 PM | ESPN | Texas | #6 Kansas | -7 | -5 | |
| 2 PM | ESPNU | Kansas State | #12 West Virginia | -5.5 | -14 | West Virginia -5.5 |
| 2 PM | ESPN2 | #17 Maryland | Purdue | 5.5 | 8 | |
| 2:30 PM | Arizona | #20 Colorado | 6 | -2 | #ppiupsetalert, Colorado +220 | |
| 3:45 PM | CBS | Washington | #8 Oregon | -2 | -2 | #ppiupsetalert, Washington +110 |
| 4 PM | ESPN | Arkansas | #10 Kentucky | 1.5 | 8 | #ppiupsetalert, Arkansas -1.5 |
| 4 PM | ESPN2 | #16 Wichita State | Houston | 3.5 | 4 | #ppiupsetalert, Houston +3.5 |
| 4 PM | ESPNU | #23 Texas Tech | Iowa State | 7.5 | 5 | |
| 4:30 PM | FS1 | #25 Creighton | Providence | 7 | 7 | |
| 5 PM | BTN | #24 Illinois | Northwestern | 12 | 15 | |
| 6 PM | ESPN | #3 Duke | #11 Louisville | 8 | 7 | |
| 8 PM | CBSSN | #7 San Diego State | Nevada | 13 | 16 | |
| 10 PM | ESPN2 | Gonzaga | BYU | 13 | 10 | |
| 12:30 PM | NBCSN | Rhode Island | La Salle | 10.5 | 7 | |
| 2 PM | CBSSN | VCU | St. Bonaventure | 9 | 7 | |
| 2 PM | ESPN+ | Pennsylvania | Saint Joseph’s | 9 | 11 | |
| 2:30 PM | NBCSN | George Mason | Richmond | -2 | 1 | |
| 4:30 PM | NBCSN | Massachusetts | George Washington | 5.5 | 8 | |
| 12 PM | ESPN | Pittsburgh | North Carolina | 4 | 6 | |
| 12 PM | ACCNX | Virginia Tech | Syracuse | 4.5 | 5 | |
| 2 PM | NC State | Clemson | 6.5 | 7 | ||
| 8 PM | ACCN | Georgia Tech | Virginia | 0 | 3 | |
| 2 PM | ESPN3 | Tulane | Tulsa | 1 | 2 | |
| 6 PM | ESPNU | UCF | South Florida | 3.5 | 8 | UCF -3.5 |
| 8 PM | ESPNU | SMU | Temple | 5 | 5 | |
| 2 PM | ESPN+ | Oklahoma | TCU | 3.5 | 4 | |
| 2 PM | FS1 | Georgetown | Marquette | 4 | 5 | |
| 6 PM | Montana State | Eastern Washington | -1.5 | 0 | ||
| 7 PM | BTN | Nebraska | Indiana | -6 | -9 | |
| 4 PM | PAC12 | Washington State | Oregon State | -4 | -1 | |
| 6:30 PM | PAC12 | USC | Stanford | 2 | 2 | |
| 9 PM | PAC12 | Arizona State | Utah | 6.5 | 7 | |
| 1 PM | SECN | Texas A&M | South Carolina | 2 | 7 | Texas A&M -2 |
| 3:30 PM | SECN | Alabama | Missouri | 7 | 9 | |
| 6 PM | SECN | Vanderbilt | Tennessee | -5 | -2 | |
| 8 PM | ESPN2 | Ole Miss | LSU | -4 | -6 | |
| 8:30 PM | SECN | Mississippi State | Georgia | 6.5 | 4 |