#ppiupsetalert record: 11-12 (.478)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN | #8 Kentucky | #4 Alabama | 2.5 | 1 | #ppiupsetalert Kentucky -132 |
| 12 PM | CBSSN | UCF | #10 Houston | -13.5 | -4 | #ppiupsetalert UCF +680 |
| 12 PM | FOX | #14 Connecticut | Creighton | 7.5 | 6 | |
| 12 PM | ESPNU | Florida State | Georgia Tech | 10.5 | 19 | Florida State -10.5 |
| 12 PM | ESPN2 | Louisville | Virginia | 16.5 | 16 | |
| 12 PM | CW | Pittsburgh | Clemson | 3.5 | 3 | |
| 12:30 PM | George Mason | George Washington | 9.5 | 11 | ||
| 1 PM | SECN | #23 Georgia | #1 Auburn | -6.5 | 0 | #ppiupsetalert, Georgia +215 |
| 1 PM | CBS | #9 Kansas | Kansas State | 14.5 | 19 | Kansas -14.5 |
| 2 PM | FOX | #7 Marquette | Xavier | 9.5 | 17 | Marquette -9.5 |
| 2 PM | CBSSN | Cincinnati | Arizona State | 10.5 | 5 | Arizona State +10.5 |
| 2 PM | ESPN2 | Texas Tech | Arizona | 3.5 | 1 | |
| 2 PM | ESPNU | Miami (FL) | SMU | -5.5 | -16 | SMU -5.5 |
| 2 PM | ACCN | Virginia Tech | Wake Forest | -4.5 | -8 | Wake Forest -4.5 |
| 2 PM | ESPN+ | Duquesne | St. Bonaventure | -2.5 | -5 | |
| 2 PM | ESPN+ | Rhode Island | Davidson | 2.5 | -2 | Davidson +116 |
| 2 PM | ESPN+ | Evansville | Belmont | -6.5 | -9 | |
| 2:15 PM | CW | North Carolina | Stanford | 11.5 | 8 | Stanford +11.5 |
| 2:30 PM | USA | Richmond | Saint Louis | -7.5 | -6 | |
| 3 PM | NBC | #13 Oregon | #17 Purdue | 2.5 | 4 | #ppiupsetalert, Purdue +126 |
| 3 PM | BTN | USC | #24 Wisconsin | -1.5 | -3 | #ppiupsetalert, USC -108 |
| 3 PM | ESPN+ | Oklahoma State | Colorado | 3.5 | 4 | |
| 3:30 PM | SECN | Vanderbilt | #6 Tennessee | -5.5 | -5 | #ppiupsetalert, Vanderbilt +198 |
| 4 PM | ESPN2 | #5 Florida | Texas | 10.5 | 15 | Florida -10.5 |
| 4 PM | ACCN | Syracuse | Notre Dame | -3.5 | 5 | Syracuse +140 |
| 4 PM | CBSSN | Dayton | Loyola (CHI) | 0 | 7 | |
| 4 PM | ESPN+ | Valparaiso | UIC | 0 | -3 | |
| 4 PM | ESPN+ | Murray State | Bradley | 0 | -2 | |
| 4 PM | Wyoming | Colorado State | 0 | -3 | ||
| 4 PM | ESPNU | Oklahoma | South Carolina | 0 | 4 | |
| 5 PM | ESPN+ | West Virginia | #2 Iowa State | -6.5 | -1 | #ppiupsetalert, West Virginia +205 |
| Illinois State | Missouri State | 8.5 | 9 | |||
| 6 PM | ACCN | NC State | California | 5.5 | 7 | |
| 8 PM | ESPN | Boston College | #3 Duke | -23.5 | -13 | Boston College +23.5 |
| 8 PM | CBSSN | San Diego State | UNLV | 10.5 | 12 | |
| 8 PM | Seton Hall | St. John’s | -9.5 | -14 | St. John’s -9.5 | |
| 8 PM | UC Riverside | UC San Diego | -9.5 | -3 | ||
| 8 PM | St. Thomas-Minnesota | Denver | 15.5 | 21 | ||
| 8 PM | ESPN+ | Idaho State | Montana | 1.5 | -2 | Montana +116 |
| 8 PM | ESPN+ | Northern Colorado | Sacramento State | 15.5 | 21 | |
| 8 PM | ESPN+ | Seattle | Southern Utah | 9.5 | 5 | |
| 8:30 PM | SECN | #11 Texas A&M | LSU | 11.5 | 12 | |
| 9 PM | ESPN+ | #16 Gonzaga | Santa Clara | 14.5 | 10 | |
| 9 PM | ESPN+ | Utah | BYU | -1.5 | 2 | Utah -104 |
| 9 PM | ESPN+ | Weber State | Montana State | -1.5 | 3 | Weber State +1.5 |
| 9 PM | ESPN+ | Loyola Marymount | San Diego | 10.5 | 20 | Loyola Marymount -10.5 |
| 10 PM | ESPN+ | San Francisco | Oregon State | 3.5 | 5 | |
| 10 PM | ESPN+ | UC Irvine | Cal Poly | 15.5 | 23 | UC Irvine -15.5 |
| 11:59 PM | ESPN+ | Hawaii | Cal State Bakersfield | 6.5 | 11 | Hawaii -6.5 |