#ppiposseofpicks: 98-125 (.439)
#ppiupsetalert: 26-31 (.456)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN2 | #3 Kansas | Kansas State | 14.5 | 20 | Kansas -14.5 |
| 7 PM | CBSSN | #9 Villanova | #13 Butler | 4.5 | 1 | #ppiupsetalert, Butler +170 |
| 7 PM | ESPN | #15 Kentucky | Georgia | 11.5 | 10 | |
| 7 PM | FS1 | Northwestern | #17 Maryland | -7.5 | -12 | Maryland -7.5 |
| 7 PM | ESPNU | Purdue | #21 Illinois | 5.5 | 4 | #ppiupsetalert, Purdue -240 |
| 8 PM | ESPN+ | TCU | #18 Texas Tech | -3 | 5 | #ppiupsetalert, TCU +132 |
| 9 PM | ESPN | #8 Duke | Miami (FL) | 17.5 | 14 | |
| 11 PM | CBSSN | #4 San Diego State | Wyoming | 23.5 | 33 | SDSU -23.5 |
| 9 PM | CBSSN | Saint Joseph’s | VCU | -11.5 | -11 | |
| 8 PM | ACCN | Clemson | Wake Forest | 8.5 | 4 | |
| 7 PM | ESPNN | South Florida | Wichita State | -4 | -7 | |
| 8 PM | ESPN+ | Iowa State | Oklahoma State | 5.5 | 3 | |
| 9 PM | FS1 | Marquette | St. John’s | 8.5 | 10 | |
| 9 PM | BTN | Wisconsin | Nebraska | 15 | 17 | |
| 7 PM | SECN | LSU | Florida | 2.5 | 5 | |
| 9 PM | ESPNU | Missouri | Texas A&M | 9 | 7 | |
| 9 PM | SECN | Tennessee | Ole MIss | 7.5 | 9 |