#ppiupsetalert record: 14-15 (.483)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | SECN | #4 Alabama | Vanderbilt | 11.5 | 7 | Vanderbilt +11.5 |
| 7 PM | ESPN2 | #6 Tennessee | #14 Mississippi State | 8.5 | 11 | |
| 7 PM | FS1 | #19 Connecticut | Butler | 12.5 | 8 | Butler +12.5 |
| 7 PM | ESPNU | Cincinnati | Texas Tech | -1.5 | 0 | |
| 7 PM | ACCN | Virginia | Boston College | 8.5 | 8 | |
| 7 PM | CBSSN | Rhode Island | VCU | -7.5 | -5 | |
| 7 PM | ESPN+ | St. Bonaventure | George Mason | 1.5 | -2 | George Mason +104 |
| 7 PM | ESPN+ | Duquesne | Dayton | -3.5 | -2 | |
| 7 PM | ESPN+ | Davidson | Saint Joseph’s | -1.5 | 4 | Davidson +100 |
| 7:30 PM | Peacock | #11 Purdue | Ohio State | 9.5 | 18 | Purdue -9.5 |
| 7:30 PM | ESPN+ | Belmont | Bradley | -2.5 | 0 | |
| 8 PM | ESPN+ | #3 Iowa State | UCF | 15.5 | 6 | UCF +15.5 |
| 8 PM | Peacock | Seton Hall | #10 Marquette | -12.5 | -20 | Marquette -12.5 |
| 8 PM | ESPN+ | Northern Iowa | Missouri State | 9.5 | 11 | |
| 8 PM | ESPN+ | Illinois State | Indiana State | 6.5 | 5 | |
| 9 PM | SECN | Texas | #22 Missouri | 2.5 | -2 | #ppiupsetalert, Texas -134 |
| 9 PM | CBSSN | #23 West Virginia | Arizona State | 8.5 | 8 | |
| 9 PM | ACCN | SMU | #25 Louisville | 1.5 | 3 | #ppiupsetalert, SMU -125 |
| 9 PM | ESPNU | Oklahoma State | Arizona | -8.5 | 2 | Oklahoma State +285 |
| 9 PM | ESPN | Wake Forest | North Carolina | 1.5 | 3 | |
| 9 PM | BTN | Iowa | Minnesota | 8.5 | 6 | |
| 9 PM | FS1 | DePaul | Creighton | -6.5 | 0 | DePaul +6.5 |
| 9:30 PM | Peacock | UCLA | #18 Wisconsin | 3.5 | -4 | #ppiupsetalert, UCLA -160 |
| 11 PM | BTN | #15 Oregon | Washington | 12.5 | 16 | Oregon -12.5 |
| 11 PM | ESPNU | Colorado | BYU | -4.5 | 2 | Colorado +164 |
| 11 PM | CBSSN | UNLV | Wyoming | 9.5 | 10 |