#ppiupsetrecord: 20-35 (36.4%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | ESPN | #6 Duke | Syracuse | 11.5 | 10 | |
| 12 PM | FOX | Georgetown | #11 Villanova | -14 | -14 | |
| 12 PM | ESPN2 | #18 Texas Tech | West Virginia | 8 | 5 | #ppiupsetalert, West Virginia +8 |
| 12 PM | FS1 | St. John’s | Seton Hall | -1 | -2 | |
| 12 PM | ESPN+ | Boston College | Virginia Tech | -6 | -3 | |
| 12 PM | BTN | Minnesota | Rutgers | 2.5 | 5 | |
| 1 PM | CBS | #2 Auburn | #12 Kentucky | 4 | 12 | Auburn -4 |
| 1 PM | SECN | Florida | Vanderbilt | 6.5 | 7 | |
| 2 PM | #23 Texas | Oklahoma State | 8.5 | 4 | #ppiupsetalert, Okla St +8.5 | |
| 2 PM | Miami (FL) | Florida State | 2.5 | 5 | ||
| 2 PM | FS1 | Air Force | Colorado State | -10.5 | -6 | Air Force +10.5 |
| 3 PM | ESPN+ | Oklahoma | #5 Baylor | -3.5 | -4 | #ppiupsetalert, Oklahoma +3.5 |
| 3 PM | UNLV | San Jose State | 13 | 8 | San Jose State +13 | |
| 3:30 PM | CBSSN | #22 Loyola (CHI) | Missouri State | 8 | 8 | |
| 3:30 PM | SECN | South Carolina | Georgia | 10 | 14 | South Carolina -10 |
| 4 PM | ESPN+ | Kansas State | #7 Kansas | -6 | -7 | |
| 4 PM | #15 Iowa State | TCU | 6.5 | 6 | ||
| 4 PM | Louisville | Notre Dame | 2.5 | 4 | ||
| 4 PM | ACCN | NC State | Virginia | 2 | 2 | |
| 4 PM | Mississippi State | Ole Miss | 11 | 11 | ||
| 4:30 PM | BTN | Iowa | Penn State | 11 | 8 | |
| 5:30 PM | CBSSN | Creighton | DePaul | 10 | 6 | DePaul +10 |
| 6 PM | #10 Houston | East Carolina | 19 | 15 | East Carolina +19 | |
| 6 PM | ESPN | #24 Tennessee | #13 LSU | 5.5 | 2 | #ppiupsetalert, Tennessee -245 |
| 6 PM | ACCN | Clemson | Pittsburgh | 9 | 10 | |
| 6 PM | SECN | Alabama | Missouri | 19 | 13 | Missouri +19 |
| 6:30 PM | PAC12 | Utah | #16 USC | -5.5 | -10 | USC -5.5 |
| 7:30 PM | CBSSN | Wyoming | New Mexico | 10.5 | 16 | Wyoming -10.5 |
| 8 PM | ACCN | Wake Forest | North Carolina | 1 | 6 | Wake Forest -1 |
| 8:30 PM | SECN | Arkansas | Texas A&M | 9 | 5 | Texas A&M +9 |
| 9 PM | Colorado | #9 UCLA | -4 | 0 | #ppiupsetalert, Colorado +4 | |
| 9:30 PM | CBSSN | San Diego State | Boise State | 4.5 | 2 | |
| 10 PM | ESPN+ | Portland State | Montana State | -3 | -4 | |
| 11 PM | Stanford | Arizona State | 5.5 | 8 |