#ppiupsetalertrecord: 21-27 (.438)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | ESPN+ | La Salle | #16 Dayton | -9.5 | -14 | Dayton -6.5 |
| 7 PM | SECN | South Carolina | #6 Kentucky | -5.5 | -1 | #ppiupsetalert, South Carolina +172 |
| 7 PM | ESPN | #11 Oklahoma | Texas | 4.5 | 9 | Oklahoma -4.5 |
| 7 PM | ACCN | Louisville | #12 Duke | -14.5 | -9 | Louisville +14.5 |
| 7 PM | BTN | Minnesota | #13 Wisconsin | -3.5 | -8 | Wisconsin -3.5 |
| 8:30 PM | FS1 | #17 Creighton | Xavier | 8.5 | 7 | |
| 9 PM | Peacock | #2 Purdue | Michigan | 18.5 | 21 | |
| 9 PM | ESPN+ | #21 BYU | #4 Houston | -2.5 | 3 | #ppiupsetalert, BYU +118 |
| 6:30 PM | FS1 | Georgetown | Butler | -3.5 | -5 | |
| 7 PM | ESPNU | Georgia Tech | Pittsburgh | -2.5 | 1 | Georgia Tech +112 |
| 7 PM | ESPN2 | Syracuse | Florida State | 3.5 | 9 | Syracuse -3.5 |
| 7 PM | ESPN+ | UCF | West Virginia | 7.5 | 15 | UCF -7.5 |
| 7 PM | Peacock | Nebraska | Ohio State | 2.5 | 6 | Nebraska -2.5 |
| 7 PM | ESPN+ | Buffalo | Ball State | -1.5 | -4 | |
| 9 PM | ACCN | Virginia Tech | Boston College | 6.5 | 9 | |
| 9 PM | ESPN2 | Oklahoma State | TCU | -4.5 | -5 | |
| 9 PM | CBSSN | San Diego State | Wyoming | 16.5 | 12 | Wyoming +16.5 |
| 9 PM | SECN | Texas A&M | Missouri | 11.5 | 14 | |
| 10:30 PM | FS1 | Fresno State | Boise State | -5.5 | -6 | |
| 11 PM | CBSSN | UNLV | Air Force | 11.5 | 11 |