#ppiupsetalert record: 16-16 (.500)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | CW | NC State | SMU | -2.5 | -7 | SMU -2.5 |
| 12:30 PM | ESPN2 | Syracuse | Pittsburgh | -7.5 | -5 | |
| 12:30 PM | FOX | Providence | Georgetown | -1.5 | 2 | Providence -114 |
| 1 PM | SECN | South Carolina | #14 Mississippi State | -7.5 | -9 | |
| 1 PM | ESPN+ | Indiana State | Northern Iowa | -3.5 | 0 | Indiana State +140 |
| 1:30 PM | CBS | Rutgers | #8 Michigan State | -5.5 | -10 | Michigan State -5.5 |
| 1:30 PM | FS1 | Creighton | Seton Hall | 14.5 | 20 | Creighton -14.5 |
| 2 PM | ESPN+ | Arizona State | #3 Iowa State | -10.5 | -2 | #ppiupsetalert, Arizona State +400 |
| 2 PM | ESPN+ | La Salle | Rhode Island | -1.5 | 0 | |
| 2 PM | ESPN+ | George Washington | Saint Louis | -1.5 | 4 | George Washington -105 |
| 2 PM | CBSSN | Bradley | Illinois State | 7.5 | 15 | Bradley -7.5 |
| 2:15 PM | CW | North Carolina | Boston College | 18.5 | 17 | |
| 2:30 PM | ESPN | Vanderbilt | #9 Kentucky | -2.5 | 7 | #ppiupsetalert, Vanderbilt +114 |
| 2:30 PM | ESPN2 | Texas | #13 Texas A&M | 1.5 | -6 | Texas A&M -111 |
| 3 PM | FOX | UNLV | New Mexico | -3.5 | -5 | |
| 3 PM | ESPN+ | Arizona | Colorado | 14.5 | 10 | Colorado +14.5 |
| 3 PM | ESPN+ | UIC | Southern Illinois | 6.5 | 13 | UIC -6.5 |
| 3:30 PM | SECN | #5 Florida | Georgia | 11.5 | 14 | |
| 3:30 PM | ESPN+ | Sam Houston State | Western Kentucky | 3.5 | 6 | |
| 4 PM | BTN | Minnesota | #15 Oregon | -4.5 | -11 | Oregon -4.5 |
| 4 PM | ESPN+ | UCF | TCU | 4.5 | 12 | UCF -4.5 |
| 4 PM | ESPN+ | Valparaiso | Evansville | 6.5 | 9 | |
| 4 PM | ESPN+ | Missouri State | Drake | -8.5 | -13 | Drake -8.5 |
| 4 PM | ESPN+ | Murray State | Belmont | 3.5 | 0 | Belmont +3.5 |
| 4 PM | Air Force | Utah State | -14.5 | -24 | Utah State -14.5 | |
| 4 PM | CBSSN | Butler | DePaul | 5.5 | 1 | DePaul +5.5 |
| 4:30 PM | ESPN | Wake Forest | #2 Duke | -11.5 | -2 | #ppiupsetalert, Wake Forest +520 |
| 4:30 PM | ESPN2 | Utah | Baylor | -3.5 | 1 | Utah +126 |
| 4:30 PM | ESPN+ | Northern Illinois | Ball State | -6.5 | -7 | |
| 5 PM | ACCN | Virginia Tech | Clemson | -9.5 | -10 | |
| 6 PM | SECN | #22 Missouri | #16 Ole Miss | 3.5 | 4 | #ppiupsetalert, Missouri -160 |
| 6 PM | CBSSN | Kansas State | #23 West Virginia | 1.5 | -5 | #ppiupsetalert, Kansas State -123 |
| 6 PM | ESPN+ | Richmond | Davidson | -4.5 | -9 | Davidson -4.5 |
| 6 PM | Oregon State | Santa Clara | 2.5 | -3 | Santa Clara +120 | |
| 6 PM | ESPN+ | Florida International | Liberty | -6.5 | -10 | Liberty -6.5 |
| 6:30 PM | ESPN | #12 Kansas | #7 Houston | -1.5 | 1 | #ppiupsetalert, Kansas -108 |
| 6:30 PM | ESPN2 | Virginia | Notre Dame | -1.5 | 7 | Virginia +106 |
| 6:30 PM | ESPNU | Louisiana Tech | Middle Tennessee | 3.5 | 4 | |
| 7 PM | Fresno State | Colorado State | -11.5 | -10 | ||
| 7 PM | ACCN | Stanford | Florida State | 4.5 | 3 | |
| 7:30 PM | San Jose State | Wyoming | 2.5 | 1 | ||
| 8 PM | FOX | Xavier | #19 Connecticut | 1.5 | 2 | |
| 8 PM | CBSSN | Washington State | Saint Mary’s | -5.5 | -4 | |
| 8 PM | ESPN+ | Portland | Gonzaga | -25.5 | -17 | Portland +25.5 |
| 8:30 PM | ESPN | #1 Auburn | #6 Tennessee | 6.5 | 8 | |
| 8:30 PM | SECN | #4 Alabama | LSU | 16.5 | 20 | Alabama -16.5 |
| 8:30 PM | ESPNU | California | Miami (FL) | 9.5 | 8 | |
| 8:30 PM | ESPN2 | Arkansas | Oklahoma | 3.5 | -5 | Oklahoma +142 |
| 9 PM | ESPN+ | Montana | Montana State | 3.5 | 8 | Montana -3.5 |
| 9 PM | ESPN+ | UTEP | Kennesaw State | 4.5 | 4 | |
| 9 PM | ESPN+ | New Mexico State | Jacksonville State | 4.5 | 3 | |
| 10 PM | CBSSN | Nevada | San Diego State | 2.5 | 0 | |
| 10 PM | ESPN+ | San Francisco | San Diego | 15.5 | 25 | San Francisco -15.5 |
| 10 PM | ESPN+ | Pepperdine | Pacific | 6.5 | 10 | Pepperdine -6.5 |
| 10:30 PM | ESPN2 | BYU | Cincinnati | 6.5 | 7 |