#ppiupsetalertrecord 43-29 (59.7%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ACCNX | #7 Virginia | Boston College | 14.5 | 17 | |
| 12 PM | ESPN | West Virginia | #15 Auburn | 4.5 | -3 | #ppiupsetalert, West Virginia -182 |
| 12:15 PM | CBS | Creighton | #13 Xavier | 5.5 | -1 | #ppiupsetalert, Creighton -205 |
| 2 PM | ESPN | Oklahoma | #2 Alabama | -5.5 | -8 | |
| 2 PM | ESPN2 | Missouri | #12 Iowa State | -1.5 | 3 | #ppiupsetalert, Missouri -102 |
| 2 PM | FS1 | DePaul | #16 Marquette | -9.5 | -10 | |
| 2:15 PM | CBS | #3 Houston | Cincinnati | 13.5 | 14 | |
| 4 PM | ESPN2 | Mississippi State | #11 TCU | -2.5 | 0 | #ppiupsetalert, Mississippi State +126 |
| 4 PM | ESPN | #17 Baylor | Arkansas | 6.5 | 9 | |
| 4 PM | #18 Charleston | Hofstra | 8.5 | 14 | Charleston -8.5 | |
| 4 PM | ESPNU | Pittsburgh | #20 Miami (FL) | -1.5 | -2 | #ppiupsetalert, Pittsburgh -105 |
| 4 PM | #21 Florida Atlantic | Western Kentucky | 12.5 | 22 | Florida Atlantic -12.5 | |
| 5 PM | ACCN | Florida State | #24 Clemson | -2.5 | 1 | #ppiupsetalert, Florida State +115 |
| 5:30 PM | FOX | Washington | #6 Arizona | -8.5 | -7 | |
| 6 PM | ESPN | #4 Tennessee | #10 Texas | 5.5 | 6 | |
| 6 PM | ESPN2 | #5 Kansas State | Florida | 4.5 | 11 | Kansas State -4.5 |
| 7 PM | Portland | #14 Gonzaga | -12.5 | -10 | ||
| 8 PM | ESPN | Kentucky | #9 Kansas | 1.5 | -1 | #ppiupsetalert, Kentucky -134 |
| 10 PM | ESPN2 | BYU | #22 Saint Mary’s | -6.5 | -8 | |
| 12 PM | ESPN2 | Notre Dame | Louisville | 8.5 | 9 | |
| 12 PM | BTN | Northwestern | Minnesota | 12.5 | 15 | |
| 1 PM | ACCN | Wake Forest | NC State | 3.5 | 1 | |
| 2 PM | ESPNU | LSU | Texas Tech | -2.5 | 9 | LSU +122 |
| 3 PM | ACCN | Georgia Tech | Duke | -8.5 | -8 | |
| 3 PM | FOX | Wisconsin | Illinois | -1.5 | 1 | |
| 4 PM | FS1 | Butler | Seton Hall | -2.5 | -1 | |
| 4:30 PM | ESPN3 | Northern Illinois | Ball State | -4.5 | -1 | |
| 4:30 PM | BTN | Maryland | Nebraska | 11.5 | 9 | |
| 6 PM | SECN | Georgia | South Carolina | 9.5 | 10 | |
| 7 PM | ACCN | Virginia Tech | Syracuse | 6.5 | 3 | |
| 7 PM | Fresno State | Utah State | -4.5 | -11 | Utah State -4.5 | |
| 8 PM | ESPNU | Washington State | Arizona State | 3.5 | -3 | Arizona State +130 |
| 8 PM | Oregon | Utah | 4.5 | 5 | ||
| 8 PM | FOX | Indiana | Ohio State | 5.5 | 9 | |
| 8 PM | CBSSN | Boise State | Colorado State | 8.5 | 16 | Boise State -8.5 |
| 8 PM | ESPN2 | Oklahoma State | Ole Miss | 9.5 | 8 | |
| 8:30 PM | SECN | Texas A&M | Vanderbilt | 9.5 | 12 | |
| 9 PM | FS1 | San Diego State | San Jose State | 13.5 | 12 | |
| 10 PM | ESPN+ | Sacramento State | Montana State | -4.5 | 1 | Sacramento State +146 |
| 10 PM | ESPNU | Stanford | California | 10.5 | 11 | |
| 10 PM | CBSSN | UNLV | Nevada | 2.5 | -6 | Nevada +110 |
| 10 PM | Oregon State | Colorado | -7.5 | -5 |