#ppiupsetalertrecord 13-12 (52.0%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | ESPN2 | #8 Tennessee | Mississippi State | 9.5 | 7 | |
| 9 PM | ESPN2 | Texas Tech | #3 Kansas | -1.5 | -7 | Kansas -1.5 |
| 9 PM | LHN | #6 Texas | Kansas State | 8.5 | 6 | |
| 9 PM | SECN | #7 Alabama | Ole Miss | 11.5 | 13 | |
| 9 PM | ACCN | Pittsburgh | #11 Virginia | -5.5 | -3 | #ppiupsetalert, Pittsburgh +5.5 |
| 9 PM | BTN | #14 Wisconsin | Minnesota | 12.5 | 17 | Wisconsin -12.5 |
| 11 PM | CBSSN | Fresno State | #21 New Mexico | -4.5 | -16 | New Mexico -4.5 |
| 7 PM | CBSSN | Toledo | Ball State | 8.5 | 13 | Toledo -8.5 |
| 6:30 PM | FS1 | St. John’s | Marquette | -2.5 | 1 | |
| 7 PM | ACCN | Boston College | Notre Dame | -2.5 | 2 | Boston College +122 |
| 7 PM | ESPNU | Louisville | Syracuse | -9.5 | -11 | |
| 7 PM | BTN | Michigan State | Nebraska | 7.5 | 5 | |
| 7 PM | SECN | Vanderbilt | South Carolina | 9.5 | 7 | |
| 8 PM | ESPN | Kentucky | LSU | 10.5 | -2 | LSU +400 |
| 8:30 PM | FS1 | Creighton | Seton Hall | 8.5 | 4 | Seton Hall +9.5 |