#ppiupsetalertrecord: 30-35 (.462)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:30 PM | SECN | #5 Tennessee | South Carolina | 14.5 | 12 | |
| 7 PM | ESPN | Georgia Tech | #3 North Carolina | -9.5 | -13 | North Carolina -9.5 |
| 7 PM | FS1 | Villanova | #9 Marquette | 1.5 | 2 | #ppiupsetalert, Villanova -132 |
| 7 PM | Peacock | Ohio State | #14 Illinois | -2.5 | -2 | #ppiupsetalert, Ohio State +114 |
| 7 PM | ESPN2 | #25 TCU | #15 Texas Tech | 4.5 | 2 | #ppiupsetalert, TCU -210 |
| 7 PM | ESPN+ | #21 Dayton | George Washington | 12.5 | 17 | Dayton -12.5 |
| 8 PM | ESPN+ | Kansas State | #23 Oklahoma | 3.5 | 2 | #ppiupsetalert, Kansas State -176 |
| 9 PM | ESPN | #8 Kansas | Oklahoma State | 15.5 | 18 | |
| 9 PM | #17 Utah State | San Jose State | 12.5 | 23 | Utah State -12.5 | |
| 7 PM | ACCN | Boston College | Syracuse | 4.5 | -1 | Syracuse +160 |
| 7 PM | BTN | Indiana | Iowa | -1.5 | 2 | Indiana -102 |
| 7 PM | ESPN+ | Ball State | Bowling Green | -1.5 | -1 | |
| 8:30 PM | SECN | Ole Miss | Mississippi State | 1.5 | 11 | Ole Miss -1.5 |
| 9 PM | CBSSN | Colorado State | San Diego State | 2.5 | 4 | |
| 9 PM | ACCN | Clemson | Louisville | 15.5 | 21 | Clemson -15.5 |
| 9 PM | ESPN2 | NC State | Miami (FL) | 4.5 | 5 | |
| 9 PM | Peacock | Michigan State | Michigan | 11.5 | 9 | |
| 9 PM | FS1 | DePaul | Seton Hall | -10.5 | -12 | |
| 9 PM | Air Force | Wyoming | 3.5 | -5 | Wyoming +138 | |
| 11 PM | UNLV | Fresno State | 8.5 | 4 | Fresno State +8.5 |