#ppiupsetalertrecord: 31-38 (.449)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 8:30 PM | FS1 | #1 Connecticut | Providence | 12.5 | 17 | Connecticut -12.5 |
| 6:30 PM | BTN | #2 Purdue | Northwestern | 13.5 | 17 | Purdue -13.5 |
| 6:30 PM | SECN | Georgia | #24 Alabama | -6.5 | -2 | #ppiupsetalert, Georgia +220 |
| 7 PM | ESPN+ | UCF | #18 Baylor | -3.5 | 0 | #ppiupsetalert, UCF +134 |
| 8 PM | ESPN | #10 Kentucky | Florida | 5.5 | 4 | |
| 9 PM | ESPN2 | #16 Auburn | Vanderbilt | 18.5 | 25 | Auburn -18.5 |
| 10:30 PM | FS1 | #19 New Mexico | Boise State | 10.5 | 11 | |
| 6:30 PM | FS1 | Xavier | St. John’s | 1.5 | 3 | |
| 7 PM | ESPN2 | Virginia | Notre Dame | 12.5 | 17 | Virginia -12.5 |
| 7 PM | ACCN | Pittsburgh | Wake Forest | 1.5 | 2 | |
| 7 PM | ESPN+ | West Virginia | Cincinnati | -3.5 | -5 | |
| 8:30 PM | BTN | Rutgers | Penn State | 6.5 | 11 | Rutgers -6.5 |
| 8:30 PM | SECN | Missouri | Arkansas | 5.5 | 0 | Arkansas +198 |