#ppiupsetalert record: 3-14 (.176)
| Time | Chan | Home | Away | Spread | Margin | |
| 6:30 PM | ACCN | Louisville | #19 Virginia Tech | 4.5 | 5 | |
| 7 PM | ESPN2 | #9 Tennessee | Arkansas | 8.5 | 4 | Arkansas +8.5, #ppiupsetalert |
| 8 PM | ESPN+ | #11 Houston | Wichita State | 11.5 | 13 | |
| 8:30 PM | BTN | #10 Michigan | #16 Minnesota | 7.5 | 7 | |
| 8:30 PM | ACNN | #21 Duke | Boston College | 12.5 | 7 | Boston College +12.5 |
| 9 PM | ESPN2 | #2 Baylor | Oklahoma | 12 | 11 | |
| 9 PM | FS1 | #7 Creighton | Seton Hall | 5 | 2 | Seton Hall +5, #ppiupsetalert |
| 9 PM | ACCNX | #22 Virginia | Wake Forest | 14.5 | 13 | |
| 4:30 PM | ACCN | Syracuse | Pittsburgh | 11.5 | 5 | Pittsburgh +11.5 |
| 7 PM | FS1 | Butler | Georgetown | 4.5 | 5 | |
| 8 PM | CBSSN | Xavier | St. John’s | 6.5 | 8 | |
| 7 PM | SECN | LSU | Georgia | 9 | 4 | Georgia +9 |
| 9 PM | ESPNU | South Carolina | Texas A&M | 4 | 3 | |
| 9 PM | SECN | Ole Miss | Auburn | 7 | 1 | Auburn +7 |