#ppiupsetalert record: 7-4 (.636)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN | #4 Duke | Notre Dame | 19.5 | 23 | Duke -19.5 |
| 12 PM | BTN | #13 Illinois | USC | 13.5 | 4 | #ppiupsetalert, USC +13.5 |
| 12 PM | ESPN2 | Pittsburgh | Louisville | 3.5 | 6 | |
| 12 PM | ESPN+ | St. Bonaventure | La Salle | 11.5 | 13 | |
| 12 PM | FOX | Butler | Creighton | -2.5 | 1 | Butler +126 |
| 1 PM | SECN | South Carolina | #2 Auburn | -16.5 | -15 | |
| 1 PM | ESPN+ | Indiana State | Belmont | 2.5 | -2 | Belmont +116 |
| 1 PM | CBS | New Mexico | San Diego State | 4.5 | 5 | |
| 1 PM | Monmouth | Charleston | -7.5 | -16 | Charleston -7.5 | |
| 1 PM | ESPN+ | New Hampshire | Binghamton | 0 | -10 | Binghamton -4.5 |
| 1 PM | Lafayette | Holy Cross | 5.5 | -5 | Holy Cross +205 | |
| 2 PM | ESPN | Texas Tech | #3 Iowa State | 2.5 | -3 | #ppiupsetalert, Texas Tech -134 |
| 2 PM | FOX | Georgetown | #9 Connecticut | -4.5 | -2 | #ppiupsetalert, Georgetown +185 |
| 2 PM | ESPN+ | Cincinnati | #11 Kansas | 1.5 | -6 | Kansas -110 |
| 2 PM | ESPN+ | #19 Memphis | East Carolina | 12.5 | 26 | Memphis -12.5 |
| 2 PM | ESPN2 | TCU | BYU | -2.5 | -4 | |
| 2 PM | ACCN | Clemson | Florida State | 8.5 | 3 | Florida State +8.5 |
| 2 PM | ESPN+ | George Mason | Massachusetts | 11.5 | 17 | George Mason -11.5 |
| 2 PM | ESPN+ | Davidson | Fordham | 8.5 | 11 | |
| 3 PM | CW | Boston College | Syracuse | 1.5 | 5 | Boston College -1.5 |
| 3 PM | CBSSN | Saint Joseph’s | Loyola (CHI) | 5.5 | 7 | |
| 3 PM | ESPN+ | UIC | Bradley | -2.5 | 1 | UIC +128 |
| 3 PM | Air Force | San Jose State | -2.5 | -5 | ||
| 3 PM | ESPN+ | Western Kentucky | Kennesaw State | 8.5 | 3 | Kennesaw State +8.5 |
| 3:30 PM | SECN | Missouri | Vanderbilt | 4.5 | -1 | Vanderbilt +172 |