#ppiupsetalert record: 4-16 (.200)
| Time | Chan | Home | Away | Spread | Margin | |
| 4:30 PM | CBS | #6 Kansas | Oklahoma | 7 | 13 | Kansas -7 |
| 12 PM | #15 Rutgers | Ohio State | 4 | 5 | ||
| 12 PM | FS1 | #7 Creighton | St. John’s | 13 | 13 | |
| 12 PM | ACCN | #21 Duke | Wake Forest | 14 | 9 | Wake Forest +14 |
| 1 PM | ESPN | #14 West Virginia | #4 Texas | 2 | 4 | West Virginia -130, #ppiupsetalert |
| 2 PM | ESPN2 | Texas A&M | #9 Tennessee | -10.5 | -7 | Tennessee +10.5 |
| 2 PM | ACCN | Boston College | #22 Virginia | -8.5 | -7 | |
| 3 PM | ESPN | TCU | #2 Baylor | -12.5 | -2 | TCU +600, #ppiupsetalert |
| 4 PM | ESPN2 | Iowa State | #18 Texas Tech | -8.5 | -6 | |
| 8 PM | Portland | #1 Gonzaga | -32.5 | -19 | Portland +32.5 | |
| 8 PM | ESPNU | #11 Houston | Tulane | 19 | 18 | |
| 8:30 PM | SECN | Ole Miss | LSU | 1.5 | 0 | |
| 6 PM | ESPN2 | Kansas State | Oklahoma State | -8 | -10 | |
| 12 PM | ACCNX | NC State | Miami (FL) | 6.5 | 9 | |
| 7 PM | ESPN | Syracuse | Georgetown | 10.5 | 12 | |
| 4 PM | CBSSN | Butler | Connecticut | -2.5 | -2 | |
| 2 PM | FS1 | DePaul | Seton Hall | -4 | -11 | Seton Hall -4 |
| 12 PM | ESPN2 | Auburn | Alabama | -5.5 | -8 | |
| 1 PM | SECN | Vanderbilt | Mississippi State | -3.5 | -3 | |
| 3:30 PM | SECN | Arkansas | Georgia | 8.5 | 9 | |
| 5 PM | ESPN | Florida | Kentucky | 4.5 | 10 | Florida -4.5 |
| 6 PM | SECN | Ole Miss | South Carolina | 1.5 | 4 | |
| 3 PM | California | Washington | 2.5 | 9 | California -2.5 | |
| 7 PM | Arizona State | USC | -2 | -7 | USC -2 | |
| 9 PM | ESPN | Arizona | UCLA | 3 | 2 | |
| 9:30 PM | Stanford | Washington State | 7.5 | 3 | Washington State +7.5 | |
| 5 PM | Buffalo | Ball State | 6.5 | 5 | ||
| 2 PM | Northern Colorado | Montana State | 2 | -2 | Montana State +115 |