#ppiupsetalertrecord: 51-65 (44.0%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 7 PM | ESPN+ | Ball State | Akron | -3.5 | -1 | |
| 9 PM | ESPN+ | Montana State | Southern Utah | 3.5 | 6 | |
| 6:30 PM | FS1 | #11 Villanova | #9 Providence | 9.5 | 5 | #ppiupsetalert, Villanova -480 |
| 6:30 PM | SECN | Georgia | #13 Tennessee | -16 | -18 | |
| 7 PM | ESPN | #7 Kentucky | Ole Miss | 17 | 18 | |
| 7 PM | BTN | #23 Ohio State | Nebraska | 15 | 16 | |
| 7 PM | ESPN+ | Detroit Mercy | Green Bay | 10.5 | 17 | Horizon Round 1: Detroit Mercy -10.5 |
| 7 PM | ESPN+ | Youngstown State | Robert Morris | 8.5 | 12 | Horizon Round 1: Youngstown State -8.5 |
| 7 PM | ESPN+ | Holy Cross | American University | 1.5 | 1 | Patriot Round 1 |
| 7 PM | ESPN+ | Lafayette | Bucknell | 5.5 | 7 | Patriot Round 1 |
| 7 PM | ESPN+ | Central Arkansas | Stetson | -1.5 | 5 | Atlantic Sun Round 1: Central Arkansas -108 |
| 7 PM | ESPN+ | Kennesaw State | Eastern Kentucky | 3.5 | 5 | Atlantic Sun Round 1 |
| 7 PM | ESPN+ | Florida Gulf Coast | North Alabama | 10.5 | 16 | Atlantic Sun Round 1: FGCU -10.5 |
| 7 PM | ESPN2 | Oklahoma | West Virginia | 5 | 7 | |
| 7 PM | ESPNU | South Carolina | Missouri | 7 | 10 | |
| 8 PM | ACCN | Pittsburgh | #4 Duke | -14.5 | -15 | |
| 8 PM | ESPN+ | TCU | #6 Kansas | -5.5 | -4 | #ppiupsetalert, TCU +5.5 |
| 8 PM | ESPN+ | Oakland | IUPUI | 23 | 27 | Horizon Round 1: Oakland -23 |
| 8 PM | ESPN+ | Milwaukee | UIC | -2.5 | -1 | Horizon Round 1 |
| 8 PM | ESPN+ | Lipscomb | North Florida | 3.5 | 2 | Atlantic Sun Round 1 |
| 8:30 PM | FS1 | Michigan | Michigan State | 5 | 2 | |
| 8:30 PM | CBSSN | VCU | St. Bonaventure | 5.5 | 6 | |
| 8:30 PM | SECN | Vanderbilt | Florida | -1 | -1 | |
| 9 PM | ESPN | #10 Wisconsin | #8 Purdue | -3 | 3 | #ppiupsetalert, Wisconsin +134 |
| 9 PM | ESPNU | #14 Houston | Cincinnati | 15 | 16 | |
| 9 PM | ESPN2 | Virginia Tech | Louisville | 10 | 11 | |
| 9 PM | Boise State | Nevada | 10 | 16 | Boise State -10 | |
| 9 PM | Air Force | San Jose State | 5.5 | 6 | ||
| 11 PM | ESPN | #16 USC | #2 Arizona | -4.5 | -2 | #ppiupsetalert, USC +4.5 |