#ppiupsetalert record: 44-43 (.511)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11:30 AM | USA | Davidson | Richmond | 5.5 | 8 | Atlantic 10 Rd 1 |
| 12 PM | ESPN2 | Georgia Tech | Virginia | 1.5 | -3 | ACC Rd 2 – Virginia +100 |
| 12:30 PM | ESPN | #10 Iowa State | Cincinnati | 8.5 | 8 | Big 12 Rd 2 |
| 1 PM | ESPN+ | Rice | Charlotte | 10.5 | 3 | AAC Rd 1 |
| 1 PM | SECN | Arkansas | South Carolina | 15.5 | -3 | SEC Rd 1 |
| 2 PM | San Jose State | Wyoming | -1.5 | 0 | Mountain West Rd 1 | |
| 2 PM | ESPN+ | Southern University | Grambling State | 5.5 | 10 | SWAC QF, Southern -5.5 |
| 2 PM | USA | Rhode Island | Fordham | 4.5 | 6 | Atlantic 10 Rd 1 |
| 2:30 PM | ESPN | North Carolina | Notre Dame | 9.5 | 13 | ACC Rd 2, North Carolina -9.5 |
| 3 PM | ESPN+ | West Virginia | Colorado | 6.5 | 4 | Big 12 Rd 2 |
| 3:30 PM | SECN | Vanderbilt | Texas | 2.5 | 3 | SEC Rd 1 |
| 3:30 PM | Peacock | Minnesota | Northwestern | -2.5 | 5 | Big Ten Rd 1, Minnesota +122 |
| 4 PM | Peacock | Providence | Butler | -1.5 | -4 | Big East Rd 1 |
| 4:30 PM | Nevada | Fresno State | 12.5 | 8 | Mountain West Rd 1, Fresno St +12.5 | |
| 4:30 PM | USA | Massachusetts | La Salle | 2.5 | 1 | Atlantic 10 Rd 1 |
| 5 PM | ESPN2 | McNeese | Lamar | 12.5 | 10 | Southland FINALS |
| 6 PM | ESPN+ | Norfolk State | Maryland-Eastern Shore | 16.5 | 16 | MEAC QF |
| 6 PM | ESPN+ | Quinnipiac | Rider | 8.5 | 5 | MAAC QF |
| 6 PM | Peacock | Ohio State | Iowa | 5.5 | 6 | Big Ten Rd 1 |
| 6:30 PM | ESPN+ | Liberty | UTEP | 7.5 | 7 | C-USA QF |
| 6:30 PM | Peacock | Georgetown | DePaul | 4.5 | 1 | Big East Rd 1, DePaul +4.5 |
| 7 PM | SECN | #25 Mississippi State | LSU | 9.5 | 13 | SEC Rd 1, Mississippi St -9.5 |
| 7 PM | CBSSN | American University | Navy | 3.5 | 9 | Patriot FINAL, American U -3.5 |
| 7 PM | UNLV | Air Force | 13.5 | 8 | Mountain West Rd 1, Air Force +13.5 | |
| 7 PM | ESPN+ | Baylor | Kansas State | 5.5 | 1 | Mountain West Rd 1, Kansas St +5.5 |
| 7 PM | ESPN2 | Stanford | California | 5.5 | 7 | ACC Rd 2 |
| 8 PM | ESPN+ | South Carolina State | Coppin State | 15.5 | 9 | MEAC QF, Coppin St +15.5 |
| 8:30 PM | ESPN+ | Jackson State | Florida A&M | 5.5 | 1 | SWAC QF, Florida A&M +5.5 |
| 8:30 PM | ESPN+ | Merrimack | Sacred Heart | 3.5 | 6 | MAAC QF |
| 8:30 PM | Peacock | Rutgers | USC | -1.5 | 1 | Big Ten Rd 1 |
| 9 PM | ESPN+ | Jacksonville State | Florida International | 7.5 | 9 | C-USA QF |
| 9 PM | ESPN+ | Utah Valley | Utah Tech | 12.5 | 15 | WAC QF |
| 9 PM | ESPN+ | UC Santa Barbara | Cal State Bakersfield | 4.5 | 6 | Big West Rd 1 |
| 9 PM | Peacock | Villanova | Seton Hall | 10.5 | 10 | Big East Rd 1 |
| 9:30 PM | SECN | Georgia | Oklahoma | 3.5 | 4 | SEC Rd 1 |
| 9:30 PM | ESPN2 | Kansas | UCF | 10.5 | 7 | Big 12 Rd 2, UCF +10.5 |
| 9:30 PM | ESPNU | SMU | Syracuse | 8.5 | 11 | ACC Rd 2 |
| 11:30 PM | ESPN2 | Northern Colorado | Montana | 2.5 | 1 | Big Sky FINALS |
| 11:30 PM | ESPN+ | Grand Canyon | UT-Arlington | 8.5 | 7 | WAC QF |
| 11:30 PM | ESPN+ | UC Davis | Cal Poly | -1.5 | -1 | Big West Rd 1 |