#ppiupsetalertrecord: 66-77 (.462)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11:30 AM | USA | George Mason | Saint Joseph’s | 1.5 | -1 | A10 Rd 2 |
| 12 PM | ESPN | Virginia Tech | Florida State | 3.5 | 2 | ACC Rd 2 |
| 12:30 PM | ESPN2 | #20 BYU | UCF | 5.5 | 5 | Big 12 Rd 2 |
| 1 PM | ESPN+ | Wichita State | Rice | 3.5 | 6 | AAC Rd 1 |
| 2 PM | USA | VCU | Fordham | 8.5 | 9 | A10 Rd 2 |
| 2 PM | Wyoming | Fresno State | 7.5 | 9 | MW Rd 1 | |
| 2:30 PM | ESPN | Wake Forest | Notre Dame | 8.5 | 6 | ACC Rd 2 |
| 3 PM | ESPN+ | Alcorn State | Alabama State | 3.5 | 3 | SWAC QFs |
| 3 PM | PAC12 | Washington | USC | -3.5 | 2 | PAC12 Rd 1, Washington +142 |
| 3 PM | ESPN+ | Temple | UTSA | -1.5 | 4 | AAC Rd 1, Temple +105 |
| 3 PM | ESPN+ | Oklahoma | TCU | -3.5 | -5 | Big 12 Rd 2 |
| 4 PM | FS1 | Butler | Xavier | -1.5 | 3 | Big East Rd 1, Butler +104 |
| 4:30 PM | Colorado State | San Jose State | 14.5 | 17 | MW Rd 1 | |
| 5 PM | ESPN2 | McNeese State | Nicholls State | 16.5 | 14 | Southland FINALS |
| 5 PM | USA | St. Bonaventure | La Salle | 7.5 | 6 | A10 Rd 2 |
| 5:30 PM | PAC12 | UCLA | Oregon State | 6.5 | 4 | PAC12 Rd 1 |
| 6 PM | ESPN+ | Norfolk State | Coppin State | 13.5 | 18 | MEAC QFs, Norfolk St -13.5 |
| 6:30 PM | Peacock | Maryland | Rutgers | 3.5 | 0 | Big Ten Rd 1, Rutgers +136 |
| 6:30 PM | ESPN+ | Quinnipiac | Canisius | 6.5 | 6 | MAAC QFs |
| 6:30 PM | FS1 | Providence | Georgetown | 9.5 | 6 | Big East Rd 1, Georgetown +9.5 |
| 6:30 PM | ESPN+ | Sam Houston State | Florida International | 6.5 | 11 | C-USA QFs, Sam Houston St -6.5 |
| 7 PM | CBSSN | Colgate | Lehigh | 8.5 | 13 | Patriot FINALS, Colgate -8.5 |
| 7 PM | New Mexico | Air Force | 14.5 | 14 | MW Rd 1 | |
| 7 PM | SECN | Arkansas | Vanderbilt | 5.5 | 6 | SEC Rd 1 |
| 7 PM | ESPN+ | Texas | Kansas State | 4.5 | 3 | Big 12 Rd 2 |
| 7 PM | ESPN2 | Syracuse | NC State | 1.5 | 6 | ACC Rd 2, Syracuse -1.5 |
| 7:30 PM | USA | Duquesne | Saint Louis | 8.5 | 11 | 4 |
| 8 PM | ESPN+ | North Carolina Central | Maryland-Eastern Shore | 9.5 | 6 | MEAC QFs – MD Eastern Shore +9.5 |
| 8:30 PM | Peacock | Penn State | Michigan | 6.5 | 2 | Big 10 Rd 1, Michigan +6.5 |
| 9 PM | ESPN+ | Fairfield | Iona | 4.5 | 3 | MAAC QFs |
| 9 PM | FS1 | Villanova | DePaul | 22.5 | 18 | Big East Rd 1, DePaul +22.5 |
| 9 PM | ESPN+ | UC Riverside | CSU Bakersfield | 1.5 | 2 | Big West Rd 1 |
| 9 PM | ESPN+ | Utah Valley | California Baptist | 5.5 | 6 | WAC Rd 1 |
| 9 PM | ESPN+ | Louisiana Tech | Middle Tennessee | 8.5 | 10 | C-USA QFs |
| 9 PM | PAC12 | California | Stanford | -1.5 | 1 | PAC12 Rd 1 |
| 9:30 PM | ESPN2 | #16 Kansas | Cincinnati | -2.5 | -9 | Big 12 Rd 2, Cincinnati -2.5 |
| 9:30 PM | ESPN+ | Grambling State | Alabama State | 1.5 | 4 | SWAC QFs |
| 9:30 PM | SECN | Georgia | Missouri | 2.5 | 6 | SEC Rd 1, Georgia -2.5 |
| 9:30 PM | ESPNU | Clemson | Boston College | 6.5 | 8 | ACC Rd 2 |
| 11:30 PM | ESPN2 | Montana | Montana State | 5.5 | 8 | Big Sky FINALS |
| 11:30 PM | ESPN+ | CS Northridge | UC Santa Barbara | -3.5 | 0 | Big West Rd 1, CS Northridge +146 |
| 11:30 PM | ESPN+ | Stephen F. Austin | Abilene Christian | 3.5 | -1 | WAC Rd 1, Abilene Christian +140 |
| 11:30 PM | PAC12 | Utah | Arizona State | 5.5 | 1 | PAC12 Rd 1, Arizona State +5.5 |