#ppiupsetalert record: 44-43 (.511)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11:30 AM | USA | Davidson | Richmond | 5.5 | 9 | Atlantic 10 Rd 1 |
| 12 PM | ESPN2 | Georgia Tech | Virginia | 1.5 | -3 | ACC Rd 2 – Virginia +100 |
| 12:30 PM | ESPN | #10 Iowa State | Cincinnati | 8.5 | 9 | Big 12 Rd 2 |
| 1 PM | ESPN+ | Rice | Charlotte | 10.5 | 2 | AAC Rd 1 |
| 1 PM | SECN | Arkansas | South Carolina | 15.5 | -3 | SEC Rd 1 |
| 2 PM | San Jose State | Wyoming | -1.5 | 1 | Mountain West Rd 1 | |
| 2 PM | ESPN+ | Southern University | Grambling State | 5.5 | 9 | SWAC QF, Southern -5.5 |
| 2 PM | USA | Rhode Island | Fordham | 4.5 | 4 | Atlantic 10 Rd 1 |
| 2:30 PM | ESPN | North Carolina | Notre Dame | 9.5 | 14 | ACC Rd 2, North Carolina -9.5 |
| 3 PM | ESPN+ | West Virginia | Colorado | 6.5 | 2 | Big 12 Rd 2 |
| 3:30 PM | SECN | Vanderbilt | Texas | 2.5 | 2 | SEC Rd 1 |
| 3:30 PM | Peacock | Minnesota | Northwestern | -2.5 | 5 | Big Ten Rd 1, Minnesota +122 |
| 4 PM | Peacock | Providence | Butler | -1.5 | -5 | Big East Rd 1 |
| 4:30 PM | Nevada | Fresno State | 12.5 | 8 | Mountain West Rd 1, Fresno St +12.5 | |
| 4:30 PM | USA | Massachusetts | La Salle | 2.5 | 0 | Atlantic 10 Rd 1 |
| 5 PM | ESPN2 | McNeese | Lamar | 12.5 | 11 | Southland FINALS |
| 6 PM | ESPN+ | Norfolk State | Maryland-Eastern Shore | 16.5 | 16 | MEAC QF |
| 6 PM | ESPN+ | Quinnipiac | Rider | 8.5 | 6 | MAAC QF |
| 6 PM | Peacock | Ohio State | Iowa | 5.5 | 5 | Big Ten Rd 1 |
| 6:30 PM | ESPN+ | Liberty | UTEP | 7.5 | 8 | C-USA QF |
| 6:30 PM | Peacock | Georgetown | DePaul | 4.5 | 0 | Big East Rd 1, DePaul +4.5 |
| 7 PM | SECN | #25 Mississippi State | LSU | 9.5 | 14 | SEC Rd 1, Mississippi St -9.5 |
| 7 PM | CBSSN | American University | Navy | 3.5 | 10 | Patriot FINAL, American U -3.5 |
| 7 PM | UNLV | Air Force | 13.5 | 9 | Mountain West Rd 1, Air Force +13.5 | |
| 7 PM | ESPN+ | Baylor | Kansas State | 5.5 | 2 | Mountain West Rd 1, Kansas St +5.5 |
| 7 PM | ESPN2 | Stanford | California | 5.5 | 7 | ACC Rd 2 |
| 8 PM | ESPN+ | South Carolina State | Coppin State | 15.5 | 9 | MEAC QF, Coppin St +15.5 |
| 8:30 PM | ESPN+ | Jackson State | Florida A&M | 5.5 | 2 | SWAC QF, Florida A&M +5.5 |
| 8:30 PM | ESPN+ | Merrimack | Sacred Heart | 3.5 | 7 | MAAC QF |
| 8:30 PM | Peacock | Rutgers | USC | -1.5 | 0 | Big Ten Rd 1 |
| 9 PM | ESPN+ | Jacksonville State | Florida International | 7.5 | 10 | C-USA QF |
| 9 PM | ESPN+ | Utah Valley | Utah Tech | 12.5 | 15 | WAC QF |
| 9 PM | ESPN+ | UC Santa Barbara | Cal State Bakersfield | 4.5 | 6 | Big West Rd 1 |
| 9 PM | Peacock | Villanova | Seton Hall | 10.5 | 11 | Big East Rd 1 |
| 9:30 PM | SECN | Georgia | Oklahoma | 3.5 | 3 | SEC Rd 1 |
| 9:30 PM | ESPN2 | Kansas | UCF | 10.5 | 7 | Big 12 Rd 2, UCF +10.5 |
| 9:30 PM | ESPNU | SMU | Syracuse | 8.5 | 12 | ACC Rd 2 |
| 11:30 PM | ESPN2 | Northern Colorado | Montana | 2.5 | 0 | Big Sky FINALS |
| 11:30 PM | ESPN+ | Grand Canyon | UT-Arlington | 8.5 | 8 | WAC QF |
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11 AM | ESPN | Akron | Bowling Green | 11.5 | 15 | MAC QF – Akron -11.5 |
| 11:30 AM | USA | St. Bonaventure | Duquesne | 2.5 | 6 | Atlantic 10 Rd 2, St. Bonaventure -2.5 |
| 12 PM | ESPN | #2 Duke | Georgia Tech | 22.5 | 18 | ACC QF, Georgia Tech +22.5 |
| 12 PM | Peacock | #6 St. John’s | Butler | 12.5 | 10 | Big East QF |
| 12 PM | BTN | Oregon | Indiana | 2.5 | 5 | Big Ten Rd 2 |
| 12:30 PM | ESPN2 | #23 BYU | #10 Iowa State | -3.5 | 1 | Big 12 QF, #ppiupsetalert, BYU +146 |
| 12:30 PM | ESPNU | Wichita State | South Florida | 3.5 | 5 | AAC Rd 2 |
| 1 PM | SECN | Ole Miss | Arkansas | 3.5 | 10 | SECN Rd 2, Ole Miss -3.5 |
| 1:30 PM | ESPN+ | Toledo | Ohio | -2.5 | 2 | MAC QF, Toledo +122 |
| 2 PM | ESPN+ | Texas Southern | Alabama State | 1.5 | -1 | SWAC QF |
| 2 PM | USA | Saint Louis | Davidson | 3.5 | 1 | Atlantic 10 Rd 2 |
| 2:30 PM | BTN | #12 Wisconsin | Northwestern | 8.5 | 12 | Big Ten Rd 2, Wisconsin -8.5 |
| 2:30 PM | Peacock | Xavier | #20 Marquette | -2.5 | -3 | Big East QF |
| 2:30 PM | ESPNU | Florida Atlantic | Charlotte | 10.5 | 7 | AAC Rd 2, Charlotte +10.5 |
| 2:30 PM | ESPN | Wake Forest | North Carolina | -5.5 | -2 | ACC QF, Wake Forest +5.5 |
| 3 PM | ESPN2 | #3 Houston | Colorado | 17.5 | 14 | Big 12 QF, Colorado +17.5 |
| 3 PM | CBSSN | New Mexico | San Jose State | 15.5 | 14 | Mountain West QF |
| 3:30 PM | SECN | #22 Texas A&M | Texas | 6.5 | 6 | SEC Rd 2 |
| 4 PM | ESPN+ | Miami (OH) | Eastern Michigan | 4.5 | 6 | MAC QF |
| 5 PM | USA | George Washington | Fordham | 6.5 | 7 | Atlantic 10 Rd 2 |
| 5:30 PM | CBSSN | San Diego State | Boise State | -2.5 | -1 | Mountain West QF |
| 6 PM | ESPN+ | Howard | Morgan State | 2.5 | -1 | MEAC QF, Morgan St +125 |
| 6 PM | ESPN+ | Iona | Manhattan | 1.5 | -1 | MAAC QF |
| 6:30 PM | BTN | Illinois | Iowa | 10.5 | 10 | Big Ten Rd 2 |
| 6:30 PM | ESPN+ | Kent State | Western Michigan | 9.5 | 10 | MAC QF |
| 6:30 PM | ESPN+ | Kennesaw State | New Mexico State | 1.5 | -2 | C-USA QF, New Mexico St -110 |
| 7 PM | ESPN | #9 Texas Tech | Baylor | 6.5 | 6 | Big 12 QF |
| 7 PM | ESPN2 | #14 Louisville | Stanford | 10.5 | 5 | ACC QF, Stanford +10.5 |
| 7 PM | SECN | #15 Missouri | #25 Mississippi State | 3.5 | -2 | SEC Rd 2, #ppiupsetalert, Mississippi St +138 |
| 7 PM | ESPNU | Temple | Tulsa | 3.5 | 6 | AAC Rd 2 |
| 7 PM | FS1 | Creighton | DePaul | 12.5 | 11 | Big East QF |
| 7:30 PM | USA | Saint Joseph’s | La Salle | 12.5 | 9 | Atlantic 10 QF – La Salle +12.5 |
| 8 PM | ESPN+ | Delaware State | North Carolina Central | 1.5 | 4 | MEAC QF |
| 8:30 PM | ESPN+ | Bethune-Cookman | Alcorn State | 3.5 | 5 | SWAC QF |
| 8:30 PM | ESPN+ | Marist | Mount St. Mary’s | 4.5 | 2 | MAAC QF |
| 9 PM | BTN | #18 Purdue | USC | 9.5 | 8 | Big Ten Rd 2 |
| 9 PM | ESPNU | East Carolina | UTSA | 4.5 | 4 | AAC Rd 2 |
| 9 PM | ESPN+ | Middle Tennessee | Louisiana Tech | 1.5 | 2 | C-USA QF |
| 9 PM | ESPN+ | Abilene Christian | Seattle | -5.5 | -2 | WAC QF, Seattle +5.5 |
| 9 PM | CBSSN | Colorado State | Nevada | 4.5 | 9 | Mountain West QF, Colorado St -4.5 |
| 9 PM | ESPN+ | Cal State Northridge | UC Santa Barbara | 3.5 | 3 | Big West QF |
| 9:30 PM | ESPN2 | #11 Clemson | SMU | 6.5 | 5 | ACC QF |
| 9:30 PM | SECN | #19 Kentucky | Oklahoma | 6.5 | 1 | SEC Rd 2, Oklahoma +6.5 |
| 9:30 PM | FS1 | Connecticut | Villanova | 6 | 5 | Big East QF |
| 9:30 PM | ESPN | #24 Arizona | Kansas | 2.5 | -2 | Big 12 QF, Kansas +128 |
| 11:30 PM | ESPN+ | California Baptist | Tarleton State | 6.5 | 3 | WAC QF, Tarleton State +6.5 |
| 11:30 PM | CBSSN | Utah State | UNLV | 7.5 | 12 | Mountain West QF – Utah St -7.5 |
| 11:30 PM | ESPN+ | UC Riverside | Cal Poly | 4.5 | 5 |