#ppiupsetalert record: 45-44 (.506)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11:30 AM | USA | VCU | St. Bonaventure | 11.5 | 10 | Atlantic 10 QF |
| 12 PM | BTN | #8 Michigan State | Oregon | 5.5 | 4 | Big Ten QF |
| 12:30 PM | CBSSN | Liberty | Kennesaw State | 6.5 | 8 | C-USA Semis |
| 1 PM | ESPN | #1 Auburn | Ole Miss | 12.5 | 10 | SEC QF |
| 1 PM | ESPN2 | #16 Memphis | Wichita State | 9.5 | 12 | AAC QF |
| 2 PM | ESPN+ | Alabama State | Grambling State | 2.5 | 6 | SWAC Semis – Alabama St -2.5 |
| 2 PM | USA | Loyola (CHI) | Saint Louis | 1.5 | 1 | Atlantic 10 QF |
| 2:30 PM | BTN | UCLA | #12 WIsconsin | -1.5 | -4 | Big Ten QF |
| 3 PM | ESPN2 | Tulane | Florida Atlantic | -3.5 | -2 | AAC QF |
| 3 PM | CBSSN | Jacksonville State | Middle Tennessee | 1.5 | -4 | C-USA Semis – Middle Tennessee -100 |
| 3:30 PM | ESPN | #4 Tennessee | Texas | 9.5 | 9 | SEC QF |
| 5 PM | CBSSN | Akron | Toledo | 8.5 | 7 | MAC Semis |
| 5 PM | USA | George Mason | George Washington | 4.5 | 4 | Atlantic 10 QF |
| 6 PM | ESPN+ | Norfolk State | Morgan State | 11.5 | 10 | MEAC Semis |
| 6 PM | ESPN+ | Quinnipiac | Iona | 4.5 | 2 | MAAC Semis |
| 6:30 PM | FOX | #6 St. John’s | #20 Marquette | 3.5 | 2 | Big East Semis |
| 6:30 PM | BTN | #13 Maryland | Illinois | 1.5 | -1 | Big Ten QF |
| 7 PM | ESPN | #2 Duke | North Carolina | 7.5 | 4 | ACC Semis – North Carolina +7.5 |
| 7 PM | ESPN2 | #3 Houston | #23 BYU | 6.5 | 6 | Big 12 Semis |
| 7 PM | SECN | #5 Florida | #15 Missouri | 8.5 | 11 | SEC QF |
| 7 PM | ESPNU | North Texas | Tulsa | 13.5 | 13 | AAC QF |
| 7:30 PM | CBSSN | Miami (OH) | Kent State | -3.5 | 0 | MAC Semis, Miami (OH) +3.5 |
| 7:30 PM | Peacock | Dayton | Saint Joseph’s | 1.5 | 3 | Atlantic 10 QF |
| 8 PM | ESPN+ | South Carolina State | North Carolina Central | 7.5 | 5 | MEAC Semis |
| 8:30 PM | ESPN+ | Jackson State | Bethune-Cookman | 3.5 | -1 | SWAC Semis – Bethune Cookman +138 |
| 8:30 PM | ESPNN | Merrimack | Mount St. Mary’s | 8.5 | 2 | MAAC Semis – Mount St. Mary’s +8.5 |
| 9 PM | BTN | #17 Michigan | #18 Purdue | -2.5 | -2 | Big Ten QF |
| 9 PM | ESPNU | UAB | East Carolina | 5.5 | 4 | AAC QF |
| 9 PM | ESPN+ | Utah Valley | Seattle | 3.5 | 6 | WAC Semis |
| 9 PM | ESPN+ | UC San Diego | UC Santa Barbara | 10.5 | 9 | Big West Semis |
| 9 PM | FOX | Creighton | Connecticut | -3.5 | -2 | Big East Semis |
| 9:30 PM | SECN | #7 Alabama | #19 Kentucky | 7.5 | 9 | SEC QF |
| 9:30 PM | ESPN2 | #9 Texas Tech | #24 Arizona | 2.5 | 2 | Big 12 Semis |
| 9:30 PM | ESPN | #14 Louisville | #11 Clemson | -1.5 | -1 | AAC Semis |
| 9:30 PM | CBSSN | New Mexico | Boise State | 1.5 | 2 | Mountain West Semis |
| 11:30 PM | ESPNU | Grand Canyon | California Baptist | 7.5 | 6 | WAC Semis |
| 11:30 PM | ESPN2 | UC Irvine | Cal Poly | 10.5 | 11 | Big West Semis |
| 11:59 PM | CBSSN | Colorado State | Utah State | 1.5 | -2 | Mountain West Semis, Utah State -110 |