#ppiupsetalertrecord: 54-65 (45.4%)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 11:30 AM | ESPN+ | Radford | North Carolina A&T | -1.5 | 7 | Big South Round 1: Radford +102 |
| 2 PM | ESPN+ | UNC Asheville | Charleston Southern | 10.5 | 17 | Big South Round 1: UNC Asheville -10.5 |
| 6 PM | ESPN+ | High Point | Hampton | 5.5 | 9 | Big South Round 1 |
| 6:30 PM | FS1 | St. John’s | Xavier | 1.5 | 2 | |
| 7 PM | SECN | #25 Alabama | Texas A&M | 10 | 11 | |
| 7 PM | Bryant University | Central Connecticut State | 16.5 | 21 | Northeast QFs: Bryant -16.5 | |
| 7 PM | Wagner | St. Francis (PA) | 10.5 | 18 | Northeast QFs: Wagner -10.5 | |
| 7 PM | Long Island | Sacred Heart | 8.5 | 13 | Northeast QFs: Long Island -8.5 | |
| 7 PM | Mount St. Mary’s | St. Francis (BKN) | 6.5 | 10 | Northeast QFs | |
| 7 PM | CBSSN | Seton Hall | Georgetown | 13.5 | 17 | Seton Hall -13.5 |
| 7 PM | ACCN | Clemson | Georgia Tech | 8.5 | 8 | |
| 7 PM | ESPN2 | Florida State | Notre Dame | -2 | -2 | |
| 7 PM | ESPN+ | Iowa State | Oklahoma State | 4 | 9 | Iowa State -4 |
| 7 PM | BTN | Indiana | Rutgers | 5 | 5 | |
| 7:30 PM | ESPN+ | Tennessee State | SIU-Edwardsville | 3.5 | 5 | OVC Round 1 (N) |
| 8 PM | ESPN+ | Campbell | Presbyterian College | 4.5 | 10 | Big South Round 1: Campbell -4.5 |
| 8:30 PM | FS1 | Creighton | #18 Connecticut | -4 | 1 | #ppiupsetalert, Creighton +4 |
| 9 PM | SECN | Mississippi State | #5 Auburn | -3.5 | -7 | |
| 9 PM | ESPN2 | #14 Arkansas | LSU | 5.5 | 7 | |
| 9 PM | CBSSN | DePaul | Marquette | -2 | -3 | |
| 9 PM | ACCNX | Wake Forest | NC State | 10 | 14 | Wake Forest -10 |
| 9 PM | ACCN | Boston College | Miami (FL) | -4 | -6 | |
| 9 PM | BTN | Maryland | Minnesota | 7 | 7 | |
| 10 PM | ESPN+ | Austin Peay | Tennessee Tech | -1.5 | 2 | OVC Round 1 (N) |
| 10:30 PM | FS1 | UNLV | Wyoming | 1.5 | 1 |