#ppiupsetalertrecord: 60-62 (.492)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN | #18 South Carolina | #24 Florida | 1.5 | 4 | |
| 1 PM | ABC | #15 Baylor | #7 Kansas | 4.5 | 4 | #ppiupsetalert, Baylor -200 |
| 1 PM | BTN | Wisconsin | #13 Illinois | 2.5 | 0 | #ppiupsetalert, Wisconsin -140 |
| 1:30 PM | CBS | #16 Kentucky | Arkansas | 13.5 | 9 | Arkansas +13.5 |
| 2 PM | ESPN | #6 Arizona | Oregon | 13.5 | 17 | Arizona -13.5 |
| 2:30 PM | FOX | #12 Creighton | #5 Marquette | 4.5 | 6 | #ppiupsetalert, Creighton -210 |
| 4 PM | ESPN+ | UCF | #8 Iowa State | -3.5 | -4 | #ppiupsetalert, UCF +140 |
| 4 PM | ESPN | #9 North Carolina | NC State | 12.5 | 15 | |
| 4 PM | ESPN2 | #11 Auburn | Mississippi State | 8.5 | 9 | |
| 4 PM | ESPN+ | Charlotte | #25 South Florida | 3.5 | 2 | #ppiupsetalert, Charlotte -170 |
| 6 PM | ESPN | #10 Duke | Virginia | 8.5 | 5 | #ppiupsetalert, Virginia +365 |
| 7 PM | PAC12 | #19 Washington State | UCLA | 6.5 | 12 | Washington State -6.5 |
| 8 PM | ESPN2 | Oklahoma | #1 Houston | -6.5 | -4 | #ppiupsetalert, Oklahoma +210 |
| 8 PM | FOX | #2 Purdue | Michigan State | 10.5 | 15 | Purdue -10.5 |
| 8 PM | ESPN | #14 Alabama | #4 Tennessee | 2.5 | -1 | #ppiupsetalert, Alabama -170 |
| 10 PM | ESPN | #17 Saint Mary’s | #23 Gonzaga | 2.5 | 0 | #ppiupsetalert, Gonzaga +120 |
| 12 PM | ESPN2 | Georgia Tech | Florida State | -1.5 | 0 | |
| 12 PM | FOX | Providence | Villanova | 2.5 | 1 | |
| 12 PM | FS1 | DePaul | Butler | -13.5 | -12 | |
| 2 PM | ESPN2 | Texas | Oklahoma State | 9.5 | 16 | Texas -9.5 |
| 3:30 PM | SECN | Vanderbilt | LSU | -3.5 | -2 | |
| 4 PM | CBS | Washington | USC | 4.5 | 9 | Washington -4.5 |
| 4 PM | Colorado State | Wyoming | 14.5 | 14 | ||
| 5 PM | ESPN+ | Eastern Washington | Montana State | 10.5 | 15 | Eastern Washington -10.5 |
| 5:30 PM | CW | Virginia Tech | Wake Forest | 1.5 | 3 | |
| 5:30 PM | BTN | Northwestern | Iowa | 3.5 | 0 | Iowa +3.5 |
| 6 PM | ACCN | Boston College | Pittsburgh | -1.5 | -3 | |
| 6 PM | ESPN2 | West Virginia | Texas Tech | -2.5 | -7 | Texas Tech -2.5 |
| 6 PM | SECN | Georgia | Texas A&M | -1.5 | -1 | |
| 7 PM | ESPN+ | Cincinnati | Kansas State | 6.5 | 4 | |
| 7:30 PM | FS1 | Georgetown | Xavier | -7.5 | -6 | |
| 7:45 PM | CW | Notre Dame | Clemson | -6.5 | -12 | Clemson -7.5 |
| 8 PM | ACCN | Louisville | Syracuse | -4.5 | -9 | Syracuse -4.5 |
| 8 PM | CBSSN | Boise State | New Mexico | 3.5 | 3 | |
| 8:30 PM | SECN | Missouri | Ole Miss | -1.5 | -11 | Ole Miss -1.5 |
| 9 PM | PAC12 | Utah | California | 8.5 | 8 | |
| 9 PM | ESPN+ | BYU | TCU | 5.5 | 7 | |
| 10 PM | CBSSN | UNLV | San Jose State | 13.5 | 13 |