#ppiupsetalert record: 46-45 (.505)
| Time | Chan | Home | Away | Spread | Expected | |
| 12:15 PM | CBS | #14 Louisville | Creighton | 2.5 | 5 | South Rd 1 (Lexington) |
| 12:40 PM | TruTV | #18 Purdue | High Point | 7.5 | 7 | Midwest Rd 1 (Providence) |
| 1:30 PM | TNT | #12 Wisconsin | Montana | 16.5 | 13 | East Rd 1 (Denver), Montana +16.5 |
| 2 PM | TBS | #3 Houston | SIU-Edwardsville | 28.5 | 25 | Midwest Rd 1 (Wichita), SIU-Edwardsville +28.5 |
| 2:50 PM | CBS | #1 Auburn | Alabama State | 31.5 | 26 | South Rd 1 (Lexington), Alabama St +31.5 |
| 3:15 PM | TruTV | #11 Clemson | McNeese | 7.5 | 6 | Midwest Rd 1 (Providence), McNeese +7.5 |
| 4:05 PM | TNT | #23 BYU | VCU | 2.5 | -3 | East Rd 1 (Denver), VCU +112 |
| 4:35 PM | TBS | Gonzaga | Georgia | 6.5 | 7 | Midwest Rd 1 (Wichita) |
| 6:50 PM | TNT | #4 Tennessee | Wofford | 18.5 | 18 | Midwest Rd 1 (Lexington) |
| 7:10 PM | CBS | Kansas | Arkansas | 4.5 | 10 | West Rd 1 (Providence), Kansas -4.5 |
| 7:25 PM | TBS | #22 Texas A&M | Yale | 7.5 | 5 | South Rd 1 (Denver) |
| 7:35 PM | TruTV | #15 Missouri | Drake | 6.5 | -4 | West Rd 1 (Wichita), , Drake +215 |
| 9:25 PM | TNT | UCLA | Utah State | 5.5 | -1 | Midwest Rd 1 (Lexington), Utah St +180 |
| 9:45 PM | CBS | #6 St. John’s | Omaha | 18.5 | 16 | West Rd 1 (Providence) |
| 10 PM | TBS | #17 Michigan | UC San Diego | 2.5 | 2 | South Rd 1 (Denver) |
| 10:10 PM | TruTV | #9 Texas Tech | UNC Wilmington | 15.5 | 3 | West Rd 1 (Wichita), UNC Wilmington +15.5 |