| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:10 PM | CBS | #18 Purdue | McNeese | 6.5 | 9 | Midwest Rd 2 (Providence) |
| 2:40 PM | CBS | #6 St. John’s | Arkansas | 6.5 | 13 | West Rd 2 (Providence) |
| 5:15 PM | CBS | #22 Texas A&M | #17 Michigan | 2.5 | -1 | South Rd 2 (Denver) |
| 6:10 PM | TNT | #9 Texas Tech | Drake | 6.5 | -1 | West Rd 2 (Wichita) |
| 7:10 PM | TBS/TruTV | #1 Auburn | Creighton | 8.5 | 11 | South Rd 2 (Lexington) |
| 7:45 PM | CBS | #12 Wisconsin | #23 BYU | 1.5 | 3 | East Rd 2 (Denver) |
| 8:40 PM | TNT | #3 Houston | Gonzaga | 4.5 | 6 | Midwest Rd 2 (Wichita) |
| 9:40 PM | TBS/TruTV | #4 Tennessee | UCLA | 5.5 | 7 |
PPI Projections: March 22, 2025
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