| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:10 PM | CBS | #5 Florida | Connecticut | 9.5 | 10 | West Rd 2 (Raleigh) |
| 2:40 PM | CBS | #2 Duke | Baylor | 14.5 | 11 | East Rd 2 (Raleigh) |
| 5:15 PM | CBS | #19 Kentucky | Illinois | -1.5 | -4 | Midwest Rd 2 (Milwaukee) |
| 6:10 PM | TNT | #7 Alabama | #21 Saint Mary’s | 5.5 | 3 | East Rd 2 (Cleveland) |
| 7:10 PM | TBS | #13 Maryland | Colorado State | 7.5 | 2 | West Rd 2 (Seattle), Colorado St +7.5 |
| 7:45 PM | TruTV | #10 Iowa State | Ole Miss | 5.5 | -1 | South Rd 2 (Milwaukee), Ole Miss +198 |
| 8:40 PM | TNT | #8 Michigan State | New Mexico | 6.5 | 7 | South Rd 2 (Cleveland) |
| 9:40 PM | TBS | #24 Arizona | Oregon | 3.5 | -2 | East Rd 2 (Seattle), Oregon +146 |
PPI Projections: March 23, 2025
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