| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7:09 PM | CBS | #8 Michigan State | Ole Miss | 3.5 | 8 | South S16 (Atlanta), Michigan St -3.5 |
| 7:39 PM | TBS/TruTV | #4 Tennessee | #19 Kentucky | 4.5 | 9 | Midwest S16 (Indianapolis), Tennessee -4.5 |
| 9:39 PM | CBS | #1 Auburn | #17 Michigan | 8.5 | 5 | South S16 (Atlanta), Michigan +8.5 |
| 10:09 PM | TBS/TruTV | #3 Houston | #18 Purdue | 8.5 | 7 | Midwest S16 (Indianapolis) |
PPI Projections: March 28, 2025
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