#ppiupsetalert record: 39-38 (.507)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | ESPN | #2 Duke | Wake Forest | 20.5 | 13 | Wake Forest +20.5 |
| 7 PM | ESPN+ | North Alabama | Austin Peay | 11.5 | 10 | Atlantic Sun QF |
| 7 PM | ESPN+ | Florida Gulf Coast | Queens University | 4.5 | 5 | Atlantic Sun QF |
| 7 PM | ESPN+ | Jacksonville | Eastern Kentucky | 2.5 | 4 | Atlantic Sun QF |
| 8 PM | ESPN+ | Lipscomb | Central Arkansas | 20.5 | 16 | Atlantic Sun QF, Central Arkansas +20.5 |
| 9 PM | ESPN | #3 Houston | Kansas | 9.5 | 12 | |
| 9 PM | FS1 | Northwestern | UCLA | -3.5 | -7 | UCLA -3.5 |
| 9 PM | ESPN+ | Montana State | Idaho | 5.5 | 6 |