#ppiupsetalertrecord 75-55 (57.7%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7:30 PM | FOX | Villanova | #14 Connecticut | -3 | -4 | #ppiupsetalert, Villanova +126 |
| 12 PM | CBS | #24 Texas A&M | #2 Alabama | 1.5 | -6 | Alabama -102 |
| 12 PM | ESPN2 | #7 Baylor | Iowa State | 7.5 | 9 | |
| 12 PM | FOX | #20 Providence | Seton Hall | 7.5 | 6 | |
| 2 PM | FOX | #6 Marquette | St. John’s | 11.5 | 13 | |
| 2 PM | ESPN+ | West Virginia | #11 Kansas State | 4.5 | -2 | #ppiupsetalert, West Virginia -215 |
| 2 PM | ESPN | Auburn | #12 Tennessee | 2.5 | 8 | #ppiupsetalert, Auburn -137 |
| 2 PM | ESPN2 | #13 Virginia | Louisville | 18.5 | 24 | Virginia -18.5 |
| 2 PM | CBS | Arkansas | #23 Kentucky | 4.5 | 8 | #ppiupsetalert, Arkansas -196 |
| 3 PM | ESPN+ | Oklahoma | #22 TCU | -2.5 | 1 | #ppiupsetalert, Oklahoma +108 |
| 4 PM | ESPN | #9 Texas | #3 Kansas | 3.5 | -2 | #ppiupsetalert, Texas -164 |
| 6 PM | ACCN | #16 Miami (FL) | #25 Pittsburgh | 7.5 | 8 | |
| 7 PM | FS1 | #19 Xavier | Butler | 12.5 | 14 | |
| 10 PM | ESPN | #4 UCLA | #8 Arizona | 4.5 | 7 | |
| 10 PM | CBSSN | #18 San Diego State | Wyoming | 13.5 | 24 | San Diego State -13.5 |
| 12 PM | William & Mary | Elon | -1.5 | 4 | CAA Rd 2 – William & Mary +108 | |
| 12 PM | ESPNN | Princeton | Pennsylvania | 2.5 | 5 | |
| 12 PM | ESPN+ | Furman | Mercer | 12.5 | 11 | SoCon QFs |
| 12 PM | ESPN+ | UNC Asheville | South Carolina Upstate | 8.5 | 7 | Big South Semis |
| 12 PM | ESPN | Michigan State | Ohio State | 7.5 | 14 | Michigan State -7.5 |
| 12:30 PM | ESPN+ | Southern Miss | South Alabama | 1.5 | 7 | Sun Belt QFs |
| 12:30 PM | USA Net | Richmond | George Mason | 1.5 | 2 | |
| 1 PM | SECN | South Carolina | Georgia | -1.5 | 0 | |
| 1 PM | Charlotte | UAB | -5.5 | 0 | Charlotte +168 | |
| 1 PM | ESPN+ | UMBC | Binghamton | 7.5 | 9 | America East QFs |
| 1 PM | ESPN+ | New Hampshire | Bryant University | -3.5 | 1 | America East QFs, New Hampshire +138 |
| 2 PM | ESPN3 | Saint Peter’s | Siena | -4.5 | -4 | |
| 2 PM | ESPN+ | La Salle | Loyola (CHI) | 3.5 | 6 | |
| 2 PM | ESPN+ | Cornell | Columbia | 16.5 | 16 | |
| 2 PM | ESPN+ | Dartmouth | Harvard | -4.5 | -2 | |
| 2 PM | ESPN+ | Fordham | Duquesne | -1.5 | 5 | Fordham -110 |
| 2 PM | ESPN+ | UTEP | Middle Tennessee | -1.5 | -2 | |
| 2 PM | ESPN3 | Manhattan | Mount St. Mary’s | 1.5 | 5 | Manhattan -1.5 |
| 2:30 PM | USA Net | Massachusetts | St. Bonaventure | 1.5 | 3 | |
| 2:30 PM | ESPNU | Boston College | Georgia Tech | 3.5 | 7 | Boston College -3.5 |
| 2:30 PM | ESPN+ | Western Carolina | East Tennessee State | -1.5 | 1 | SoCon QFs |
| 2:30 PM | Drexel | Monmouth | 9.5 | 8 | CAA Rd 2 | |
| 2:30 PM | ESPN+ | Radford | Campbell | 3.5 | 5 | |
| 3 PM | North Texas | Western Kentucky | 9.5 | 17 | North Texas -9.5 | |
| 3 PM | ESPN+ | James Madison | Troy | 3.5 | 3 | Sun Belt QFs |
| 3 PM | Rice | Florida International | 5.5 | 10 | Rice -5.5 | |
| 3:30 PM | SECN | Missouri | Ole Miss | 8.5 | 12 | Missouri -8.5 |
| 3:30 PM | CBSSN | Bradley | Indiana State | 2.5 | 5 | MVC Semis |
| 3:30 PM | ESPN3 | Canisius | Niagara | 2.5 | 2 | |
| 4 PM | CBS | Oregon | Stanford | 6.5 | 10 | Oregon -6.5 |
| 4 PM | ESPN2 | Virginia Tech | Florida State | 9.5 | 11 | |
| 4 PM | Prairie View A&M | Texas Southern | 3.5 | 5 | ||
| 4 PM | ESPN+ | UMass Lowell | Maine | 10.5 | 13 | America East QFs |
| 4 PM | Bethune-Cookman | Florida A&M | 3.5 | 5 | ||
| 4 PM | Air Force | San Jose State | 1.5 | -3 | San Jose State +106 | |
| 4 PM | ESPN+ | UC Davis | Long Beach State | 3.5 | 3 | |
| 4:30 PM | USA Net | George Washington | VCU | -7.5 | -6 | |
| 5 PM | Nevada | UNLV | 8.5 | 10 | ||
| 5 PM | ACCNX | Syracuse | Wake Forest | 0.5 | 3 | |
| 5:30 PM | PAC12 | Colorado | Utah | 5.5 | 4 | |
| 6 PM | CBSSN | Drake | Southern Illinois | 4.5 | 4 | MVC Semis |
| 6 PM | SECN | Florida | LSU | 6.5 | 8 | |
| 6 PM | ESPN2 | Texas Tech | Oklahoma State | 5.5 | 6 | |
| 6 PM | ESPN+ | Marshall | Texas State | 7.5 | 12 | Sun Belt QFs, Marshall -7.5 |
| 6 PM | North Carolina A&T | Stony Brook | 1.5 | 4 | CAA Rd 2 | |
| 6 PM | ESPN+ | Samford | Chattanooga | 1.5 | 6 | SoCon QFs, Samford -1.5 |
| 6:30 PM | ESPN | North Carolina | Duke | 3.5 | 2 | |
| 6:30 PM | Southern University | Alabama A&M | 6.5 | 8 | ||
| 6:30 PM | Arkansas-Pine Bluff | Alcorn State | -2.5 | -5 | ||
| 6:30 PM | Grambling State | Alabama State | 11.5 | 17 | Grambling State -11.5 | |
| 7 PM | ESPN+ | Oral Roberts | North Dakota | 16.5 | 16 | Summit QFs |
| 7 PM | ESPN+ | Louisiana Tech | Florida Atlantic | -8.5 | -11 | |
| 7 PM | ESPN+ | Mississippi Valley State | Jackson State | -3.5 | -5 | |
| 7 PM | ESPN3 | Rider | Iona | -7.5 | -5 | |
| 7 PM | ESPN+ | Vermont | NJIT | 18.5 | 19 | America East QFs |
| 7 PM | Fresno State | Chicago State | 12.5 | 12 | ||
| 7:30 PM | ESPN+ | Northern Arizona | Idaho | 3.5 | 3 | Big Sky Rd 1 |
| 8 PM | PAC12 | Oregon State | California | 6.5 | 9 | |
| 8 PM | ACCN | Clemson | Notre Dame | 9.5 | 18 | Clemson -9.5 |
| 8 PM | CBSSN | Rhode Island | Davidson | -4.5 | -3 | |
| 8 PM | ESPN2 | Tennessee Tech | Southeast Missouri State | 1.5 | 0 | OVC Finals |
| 8 PM | ESPN3 | Fairleigh Dickinson | St. Francis (PA) | 3.5 | 6 | |
| 8:30 PM | SECN | Vanderbilt | Mississippi State | -3.5 | -3 | |
| 8:30 PM | ESPN+ | Louisiana Lafayette | Georgia Southern | 9.5 | 9 | Sun Belt QFs |
| 8:30 PM | ESPN+ | UNC Greensboro | Wofford | 6.5 | 3 | SoCon QFs – UNC Greensboro -6.5 |
| 8:30 PM | Delaware | Northeastern | 5.5 | 4 | CAA Rd 2 | |
| 9 PM | ESPNU | UC Santa Barbara | Hawaii | 4.5 | 3 | |
| 9 PM | Utah State | Boise State | 4.5 | 3 | ||
| 9 PM | FS1 | DePaul | Creighton | -12.5 | -11 | |
| 9 PM | ESPN+ | UC Irvine | CSU Bakersfield | 16.5 | 18 | |
| 9:30 PM | ESPN+ | South Dakota State | Omaha | 11.5 | 11 | Summit QFs |
| 10 PM | ESPN+ | Portland State | Northern Colorado | -3.5 | -1 | Big Sky Rd 1 |
| 10 PM | ESPN2 | Loyola Marymount | BYU | -4.5 | 2 | Loyola Marymount +162 |
| 10 PM | ESPN+ | Cal Poly | UC Riverside | -7.5 | -11 | UC Riverside -7.5 |
| 11 PM | FS1 | USC | Arizona State | 5.5 | 6 | |
| 12:30 AM | ESPN2 | Santa Clara | San Francisco | 4.5 | 5 | WCC Rd 2 |