#ppiupsetalertrecord: 63-69 (.477)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | Peacock | #13 Illinois | #2 Purdue | 1.5 | -2 | #ppiupsetalert, Illinois -130 |
| 7 PM | ACCN | #9 North Carolina | Notre Dame | 15.5 | 22 | North Carolina -15.5 |
| 7 PM | ESPN | #24 Florida | #14 Alabama | 1.5 | 2 | #ppiupsetalert, Florida -118 |
| 7 PM | ESPN+ | #25 South Florida | Tulane | 7.5 | 11 | South Florida -7.5 |
| 9 PM | SECN | Missouri | #11 Auburn | -11.5 | -17 | Auburn -11.5 |
| 9 PM | ESPN | #7 Kansas | Kansas State | 10.5 | 9 | |
| 9 PM | CBSSN | Saint Louis | #21 Dayton | -8.5 | -14 | Dayton -8.5 |
| 11 PM | CBSSN | UNLV | #20 San Diego State | -2.5 | -4 | |
| 6 PM | ESPN+ | Army | Holy Cross | 4.5 | 5 | Patriot League – Round 1 |
| 6 PM | ESPN+ | UL Monroe | Coastal Carolina | 1.5 | 2 | Sun Belt – Round 1 |
| 7 PM | ESPN+ | Navy | Loyola (MD) | 7.5 | 9 | Patriot League – Round 1 |
| 7 PM | ESPN+ | Cleveland State | IUPUI | 16.5 | 21 | Horizon – Round 1, Cleveland St -16.5 |
| 7 PM | ESPN+ | Purdue Fort Wayne | Robert Morris | 10.5 | 12 | Horizon – Round 1 |
| 7 PM | ESPN+ | Eastern Kentucky | Jacksonville | 8.5 | 6 | Atlantic Sun QFs |
| 7 PM | ESPN+ | Stetson | Queens University | 5.5 | 8 | |
| 7 PM | ESPNU | Louisville | Virginia Tech | -7.5 | -7 | |
| 7 PM | ESPN2 | Clemson | Syracuse | 9.5 | 7 | |
| 7 PM | FS1 | Georgetown | Providence | -7.5 | -3 | Georgetown +7.5 |
| 7 PM | SECN | Georgia | Ole Miss | 2.5 | -3 | Ole Miss +116 |
| 7 PM | ESPN+ | Ball State | Kent State | -1.5 | -2 | |
| 8 PM | ESPN+ | Milwaukee | Detroit Mercy | 11.5 | 21 | Horizon – Round 1, Milwaukee -11.5 |
| 8 PM | ESPN+ | Austin Peay | North Florida | 2.5 | 7 | Atlantic Sun QFs, Austin Peay -2.5 |
| 8 PM | ESPN+ | Lipscomb | North Alabama | 7.5 | 9 | Atlantic Sun QFs |
| 8 PM | ESPN+ | Oklahoma State | Texas Tech | -2.5 | -8 | Texas Tech -2.5 |
| 8 PM | ESPN+ | Oklahoma | Cincinnati | 5.5 | 6 | |
| 8:30 PM | ESPN+ | Texas State | Old Dominion | 2.5 | 4 | Sun Belt – Round 1 |
| 8:30 PM | Wyoming | Air Force | 6.5 | 12 | Wyoming -6.5 | |
| 9 PM | ACCN | Wake Forest | Georgia Tech | 13.5 | 8 | Georgia Tech +13.5 |
| 9 PM | ESPN2 | Pittsburgh | Florida State | 7.5 | 8 | |
| 9 PM | FS1 | DePaul | St. John’s | -19.5 | -14 | DePaul +19.5 |
| 11 PM | FS1 | Boise State | Nevada | 5.5 | 4 |