#ppiupsetalertrecord: 64-70 (.478)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 7 PM | ESPN+ | UCF | #1 Houston | -8.5 | -6 | |
| 7 PM | ESPN2 | #17 South Carolina | #4 Tennessee | -5.5 | -2 | #ppiupsetalert, South Carolina +198 |
| 8:30 PM | FS1 | #8 Marquette | #2 Connecticut | -5.5 | -10 | Connecticut -5.5 |
| 9 PM | ESPN2 | #6 Iowa State | #20 BYU | 6.5 | 5 | #ppiupsetalert, BYU +245 |
| 9 PM | SECN | #15 Kentucky | Vanderbilt | 17.5 | 17 | |
| 9:30 PM | CBSSN | San Jose State | #22 Utah State | -10.5 | -15 | Utah State -10.5 |
| 6:30 PM | FS1 | Seton Hall | Villanova | 1.5 | 2 | |
| 7 PM | Central Connecticut State | St. Francis (PA) | 14.5 | 16 | Northeast – QF | |
| 7 PM | Merrimack | Long Island | 14.5 | 16 | Northeast – QF | |
| 7 PM | Sacred Heart | Wagner | 5.5 | 6 | Northeast – QF | |
| 7 PM | Le Moyne | Fairleigh Dickinson | 3.5 | 3 | Northeast – QF | |
| 7 PM | ESPNU | Miami (FL) | Boston College | 6.5 | 5 | |
| 7 PM | ESPN+ | West Virginia | TCU | -4.5 | -7 | |
| 7 PM | BTN | Michigan State | Northwestern | 9.5 | 11 | |
| 7 PM | SECN | Arkansas | LSU | 3.5 | 5 | |
| 7:30 PM | ESPN+ | Tennessee State | Southern Indiana | 3.5 | 8 | OVC – Rd 1 – Tennessee State -3.5 |
| 7:30 PM | CBSSN | Butler | Xavier | 2.5 | 4 | |
| 8 PM | ESPN+ | Radford | South Carolina Upstate | 4.5 | 3 | Big South – Rd 1 |
| 9 PM | BTN | Minnesota | Indiana | 5.5 | 2 | Indiana +5.5 |
| 9 PM | ESPNU | Texas A&M | Mississippi State | 2.5 | -1 | Mississippi State +112 |
| 10 PM | ESPN+ | SIU-Edwardsville | Eastern Illinois | 3.5 | 7 | OVC – Rd 1, SIU-Edwardsville -2.5 |
| 10:30 PM | FS1 | New Mexico | Fresno State | 17.5 | 20 |