#ppiupsetalert record: 51-48 (.515)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 12 PM | CBS | #9 Houston | Memphis | 9.5 | 10 | |
| 12:30 PM | FOX | #5 Iowa | #25 Wisconsin | 6.5 | 12 | Iowa -6.5 |
| 2:10 PM | CBS | #20 Loyola (CHI) | Drake | 7 | 1 | #ppiupsetalert, Drake +260 |
| 4 PM | ESPN | #3 Baylor | #18 Texas Tech | 8 | 12 | Baylor -8 |
| 4:30 PM | CBS | Michigan State | #2 Michigan | -7.5 | -10 | |
| 7 PM | ESPN+ | TCU | #15 Texas | -7.5 | -5 | #ppiupsetalert |
| 12 PM | ESPNU | Tennessee | Florida | 4.5 | 4 | |
| 1:30 PM | BTN | Northwestern | Nebraska | 7 | 6 | |
| 7 PM | Maryland | Penn State | 5.5 | 9 | Maryland -5.5 | |
| 8 PM | FS1 | Oregon State | Oregon | -5.5 | -2 | Oregon State +205 |