#ppiupsetalert record: 43-40 (.518)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:30 PM | ESPN+ | High Point | Gardner-Webb | 16.5 | 13 | Big South QF – Gardner-Webb +16.5 |
| 1 PM | ESPN+ | Drake | Southern Illinois | 10.5 | 12 | MVC QF |
| 2 PM | Delaware | Stony Brook | 7.5 | 4 | CAA Rd 1 – Stony Brook +7.5 | |
| 2:30 PM | ESPN+ | Radford | Presbyterian College | 3.5 | 4 | Big South QF |
| 3:30 PM | ESPN+ | Belmont | Illinois State | 1.5 | 3 | MVC QF |
| 4:30 PM | ESPN+ | Hofstra | North Carolina A&T | 8.5 | 8 | |
| 5 PM | ESPN+ | Mercer | Western Carolina | 6.5 | 2 | Western Carolina +6.5 |
| 6 PM | ESPN+ | Marshall | Georgia State | 5.5 | 6 | Sun Belt – Rd 4 |
| 6 PM | ESPN+ | UNC Asheville | Charleston Southern | 5.5 | 9 | Big South QF |
| 6 PM | ESPNU | Miami (OH) | Ball State | 19.5 | 11 | |
| 7 PM | ESPN+ | Bradley | Murray State | 4.5 | 7 | MVC QF |
| 7 PM | ESPN2 | VCU | Dayton | 9.5 | 7 | |
| 7:30 PM | ESPN+ | VMI | The Citadel | 5.5 | 6 | SoCon Rd 1 |
| 8 PM | FOX | Illinois | #18 Purdue | 4.5 | 0 | #ppiupsetalert, Illinois -194 |
| 8 PM | ESPNU | Southeast Missouri State | Little Rock | 3.5 | 3 | OVC Semis |
| 8:30 PM | ESPN+ | App State | Old Dominion | 7.5 | 6 | Sun Belt – Rd 4 |
| 8:30 PM | ESPN+ | Winthrop | Longwood | 4.5 | 3 | Big South – QF |
| 9 PM | ESPN2 | #16 Memphis | South Florida | 12.5 | 21 | Memphis -12.5 |
| 9 PM | ESPN+ | Portland | Pepperdine | 1.5 | 3 | West Coast Rd 2 |
| 9:30 PM | South Dakota State | North Dakota | 7.5 | 9 | Summit QF | |
| 9:30 PM | ESPN+ | Northern Iowa | Valparaiso | 8.5 | 9 | MVC QF |
| 10 PM | CBSSN | New Mexico | UNLV | 11.5 | 16 | New Mexico -11.5 |
| 10 PM | FS1 | Boise State | Colorado State | 6.5 | 4 | |
| 10:30 PM | ESPNU | SIU-Edwardsville | Tennessee State | 2.5 | 4 | OVC Semis |
| 11:30 PM | ESPN+ | Loyola Marymount | San Diego | 8.5 | 12 | West Coast Rd 2, Loyola Marymount -8.5 |