#ppiupsetalertrecord 80-58 (58.0%)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11 AM | ESPN+ | Toledo | Miami (OH) | 13.5 | 17 | MAC QF – Toledo -6.5 |
| 11:30 AM | USA Net | VCU | Davidson | 6.5 | 8 | A-10 QF |
| 12 PM | FS1 | #6 Marquette | St. John’s | 6.5 | 13 | Big East QF, Marquette -6.5 |
| 12 PM | ESPN2 | #14 Miami (FL) | Wake Forest | 5.5 | 10 | ACC QF – Miami (FL) -5.5 |
| 12 PM | BTN | Michigan | Rutgers | 2.5 | 3 | Big Ten Rd 2 |
| 12:30 PM | ESPN | #10 Baylor | Iowa State | 4.5 | 0 | Big 12 QF, #ppiupsetalert, Iowa State +160 |
| 12:30 PM | ESPNU | South Florida | East Carolina | 2.5 | 1 | AAC Rd 1 |
| 1 PM | SECN | Florida | Mississippi State | -3.5 | -8 | SEC Rd 2 – Mississippi State -3.5 |
| 1:30 PM | ESPN+ | Ball State | Ohio | 1.5 | -2 | MAC QF – Ohio -106 |
| 2 PM | USA Net | Saint Louis | George Mason | 4.5 | 5 | A-10 QF |
| 2:30 PM | FS1 | #11 Connecticut | Providence | 6.5 | 6 | Big East QF |
| 2;30 PM | ESPN2 | #21 Duke | Pittsburgh | 5.5 | 5 | ACC QF |
| 2:30 PM | ESPNU | UCF | SMU | 6.5 | 8 | AAC Rd 1 |
| 2:30 PM | BTN | Iowa | Ohio State | 3.5 | 8 | Big Ten Rd 2 – Iowa -3.5 |
| 3 PM | PAC12 | #2 UCLA | Colorado | 8.5 | 14 | PAC 12 QF – UCLA -8.5 |
| 3 PM | ESPN | #3 Kansas | West Virginia | 3.5 | 3 | Big 12 QF |
| 3 PM | SECN | #17 Tennessee | Ole Miss | 11.5 | 8 | SEC Rd 2 – Ole Miss +11.5 |
| 3 PM | CBSSN | #20 San Diego State | Colorado State | 8.5 | 12 | MW QF – San Diego St -8.5 |
| 3 PM | ESPN+ | Jackson State | Prairie View A&M | -1.5 | 0 | SWAC QF |
| 3 PM | ESPN+ | Sam Houston State | California Baptist | 5.5 | 9 | WAC QF – Sam Houston St -5.5 |
| 3 PM | ESPN+ | UC Irvine | CSU Bakersfield | 11.5 | 16 | Big West QF – UC Irvine -10.5 |
| 4 PM | ESPN+ | Kent State | Northern Illinois | 11.5 | 14 | MAC QF |
| 5 PM | ESPN+ | Seattle | Grand Canyon | -2.5 | 1 | WAC QF – Seattle +118 |
| 5 PM | USA Net | Dayton | Saint Joseph’s | 10.5 | 7 | A-10 QF – Saint Joseph’s +10.5 |
| 5:30 PM | CBSSN | Nevada | San Jose State | 4.5 | 4 | MW QF |
| 5:30 PM | PAC12 | Oregon | Washington State | 2.5 | 1 | PAC 12 QF |
| 5:30 PM | ESPN+ | Cal State Fullerton | Hawaii | -1.5 | -3 | Big West QF |
| 6 PM | ESPN+ | Maryland-Eastern Shore | Morgan State | 5.5 | 3 | MEAC QF |
| 6:30 PM | ESPN+ | Florida Atlantic | Western Kentucky | 10.5 | 15 | C-USA QF – Florida Atlantic -10.5 |
| 6:30 PM | BTN | Illinois | Penn State | 2.5 | 0 | Big Ten Rd 2 |
| 6:30 PM | ESPN+ | Akron | Buffalo | 7.5 | 5 | MAC QF |
| 7 PM | ESPN2 | #7 Texas | Oklahoma State | 6.5 | 8 | Big 12 QF |
| 7 PM | ESPN | #13 Virginia | North Carolina | 1.5 | 2 | ACC QF |
| 7 PM | FS1 | #15 Xavier | DePaul | 12.5 | 10 | Big East QF |
| 7 PM | SECN | Auburn | Arkansas | -2.5 | 1 | SEC Rd 2 – Auburn +108 |
| 7 PM | ESPN+ | Middle Tennessee | Charlotte | 0.5 | 0 | C-USA QF |
| 7 PM | ESPNU | Wichita State | Tulsa | 15.5 | 11 | AAC Rd 1 – Tulsa +15.5 |
| 7 PM | ESPN+ | Quinnipiac | Marist | 6.5 | 10 | MAAC QF – Quinnipiac -6.5 |
| 7:30 PM | USA Net | Fordham | La Salle | 5 | 10 | A-10 QF – Fordham -5 |
| 8 PM | ESPN+ | Norfolk State | Coppin State | 10.5 | 10 | MEAC QF |
| 9 PM | PAC12 | #8 Arizona | Stanford | 8.5 | 13 | PAC 12 QF – Arizona -8.5 |
| 9 PM | SECN | Vanderbilt | LSU | 3.5 | 3 | SEC Rd 2 |
| 9 PM | ESPN+ | North Texas | Louisiana Tech | 7.5 | 9 | C-USA QF |
| 9 PM | CBSSN | Boise State | UNLV | 5.5 | 8 | MW QF |
| 9 PM | BTN | Maryland | Minnesota | 12.5 | 13 | Big Ten Rd 2 |
| 9 PM | ESPN+ | Utah Valley | Tarleton State | 6.5 | 7 | WAC QF |
| 9 PM | ESPN+ | UC Santa Barbara | Cal Poly | 10.5 | 14 | Big West QF – UC Santa Barbara -10.5 |
| 9:30 PM | ESPN2 | #12 Kansas State | #22 TCU | -2.5 | 6 | Big 12 QF, Kansas State +112 |
| 9:30 PM | FS1 | #24 Creighton | Villanova | 4.5 | 4 | Big East QF |
| 9:30 PM | ESPN+ | Southern University | Alabama A&M | 2.5 | 5 | SWAC QF |
| 9;30 PM | ESPN+ | UAB | Rice | 12.5 | 8 | C-USA QF – Rice +12.5 |
| 9:30 PM | ESPN+ | Siena | Niagara | 1.5 | 3 | MAAC QF |
| 9:30 PM | ESPN | Clemson | NC State | -1.5 | -1 | ACC QF |
| 11 PM | ESPN+ | Southern Utah | Utah Tech | 3.5 | 6 | WAC QF |
| 11:30 PM | CBSSN | Utah State | New Mexico | 3.5 | 2 | MW QF |
| 11:30 PM | ESPN | USC | Arizona State | 2.5 | 2 | PAC 12 QF |
| 11:30 PM | ESPN+ | UC Riverside | UC Davis | 1.5 | 4 | Big West QF |