#ppiupsetalertrecord: 64-72 (.471)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | ESPN | #16 Alabama | Arkansas | 14.5 | 12 | |
| 2 PM | ESPN2 | Kansas State | #6 Iowa State | -3.5 | -4 | #ppiupsetalert, Kansas State +136 |
| 2:30 PM | FOX | Villanova | #10 Creighton | -1.5 | 0 | #ppiupsetalert, Villanova +105 |
| 2:30 PM | SECN | Mississippi State | #17 South Carolina | 5.5 | 0 | #ppiupsetalert, Mississippi St -225 |
| 3 PM | ESPN+ | Tulsa | #24 South Florida | -4.5 | -6 | |
| 4 PM | ESPN | #1 Houston | #14 Kansas | 7.5 | 10 | |
| 4 PM | CBS | #4 Tennessee | #15 Kentucky | 7.5 | 12 | Tennessee -7.5 |
| 5 PM | FOX | Xavier | #8 Marquette | -2.5 | 1 | #ppiupsetalert, Xavier +122 |
| 6 PM | ESPN2 | Texas Tech | #11 Baylor | 1.5 | 3 | #ppiupsetalert, Texas Tech -132 |
| 6:30 PM | ESPN | #9 Duke | #7 North Carolina | 4.5 | -2 | #ppiupsetalert, Duke -215 |
| 6:30 PM | SECN | #13 Auburn | Georgia | 15.5 | 18 | |
| 8 PM | FOX | Providence | #2 Connecticut | -9.5 | -11 | |
| 8:30 PM | CBSSN | #22 Utah State | New Mexico | 3.5 | 6 | |
| 9 PM | ESPN+ | #20 BYU | Oklahoma State | 13.5 | 19 | BYU -13.5 |
| 10 PM | ESPN | USC | #5 Arizona | -7.5 | -12 | Arizona -7.5 |
| 12 PM | Monmouth | Campbell | 4.5 | 7 | CAA Rd 2 | |
| 12 PM | ESPN+ | Merrimack | Le Moyne | 7.5 | 12 | Northeast Semis, Merrimack -7.5 |
| 12 PM | ESPN+ | Samford | Mercer | 8.5 | 10 | SoCon QFs |
| 12 PM | ESPN+ | High Point | Longwood | 7.5 | 12 | Big South Semis, High Point -7.5 |
| 12 PM | CBS | Florida Atlantic | Memphis | 6.5 | 7 | |
| 12 PM | FOX | St. John’s | Georgetown | 18.5 | 16 | |
| 12:30 PM | ESPN+ | Appalachian State | Georgia Southern | 13.5 | 21 | Sun Belt QFs, Appalachian St -13.5 |
| 2 PM | ESPN+ | Central Connecticut State | Wagner | 6.5 | 10 | Northeast Semis, CCSU -6.5 |
| 2 PM | ESPN+ | Bryant University | Maine | 4.5 | 8 | America East QFs, Bryant -4.5 |
| 2 PM | ESPN+ | UNC Asheville | Gardner-Webb | 3.5 | 5 | |
| 2 PM | ESPN | Texas | Oklahoma | 5.5 | 5 | |
| 2 PM | ESPN+ | Cincinnati | West Virginia | 11.5 | 11 | |
| 2 PM | CBS | Ole Miss | Texas A&M | 1.5 | 7 | Ole Miss -1.5 |
| 2:30 PM | Towson | William & Mary | 11.5 | 13 | CAA Rd 2 | |
| 2:30 PM | ESPN+ | UNC Greensboro | East Tennessee State | 6.5 | 5 | SoCon QFs |
| 2:30 PM | ESPNU | Virginia Tech | Notre Dame | 9.5 | 12 | |
| 2:30 PM | George Mason | Richmond | 2.5 | -3 | Richmond +114 | |
| 3 PM | ESPN+ | Vermont | Albany | 17.5 | 11 | America East QFs, Albany +17.5 |
| 3 PM | ESPN+ | New Hampshire | Binghamton | 2.5 | 4 | America East QFs |
| 3 PM | ESPN+ | UMass Lowell | UMBC | 8.5 | 15 | America East QFs, UMass Lowell -8.5 |
| 3 PM | ESPN+ | Arkansas State | Louisiana Lafayette | 1.5 | 2 | Sun Belt QFs |
| 3 PM | ESPN+ | Sam Houston State | Jacksonville State | 6.5 | 11 | Sam Houston St -6.5 |
| 3:30 PM | CBSSN | Indiana State | Northern Iowa | 7.5 | 8 | MVC Semis |
| 4 PM | ESPN2 | Florida State | Miami (FL) | 4.5 | 5 | |
| 4 PM | ESPN+ | East Carolina | Charlotte | 2.5 | -3 | Charlotte +114 |
| 4 PM | Air Force | Colorado State | -10.5 | -14 | Colorado State -10.5 | |
| 4:30 PM | SECN | Vanderbilt | Florida | -9.5 | -11 | |
| 5 PM | PAC12 | Oregon State | Colorado | -8.5 | -5 | Oregon State +8.5 |
| 5 PM | ESPN+ | TCU | UCF | 7.5 | 7 | |
| 5 PM | Alabama A&M | Southern University | -3.5 | -8 | Southern University -3.5 | |
| 5 PM | ESPN+ | Tarleton State | Seattle | 2.5 | 7 | Tarleton State -2.5 |
| 5:30 PM | CW | Louisville | Boston College | -4.5 | -4 | |
| 6 PM | Stony Brook | Northeastern | 1.5 | 3 | CAA Rd 2 | |
| 6 PM | CBSSN | Drake | Bradley | 1.5 | 4 | MVC Semis |
| 6 PM | ESPN+ | Troy | Texas State | 5.5 | 6 | Sun Belt QFs |
| 6 PM | ESPN+ | Chattanooga | Wofford | 4.5 | 1 | SoCon QFs, Wofford +4.5 |
| 6 PM | ACCN | Wake Forest | Clemson | 3.5 | -3 | Clemson +138 |
| 6 PM | ESPN+ | Pennsylvania | Princeton | -6.5 | -11 | Princeton -6.5 |
| 6 PM | ESPN+ | Long Beach State | UC Davis | 2.5 | 6 | Long Beach St -2.5 |
| 7 PM | South Dakota State | Oral Roberts | 7.5 | 10 | Summit QFs | |
| 7 PM | PAC12 | Oregon | Utah | 3.5 | 2 | |
| 7 PM | Fresno State | Wyoming | 1.5 | -4 | Wyoming -110 | |
| 7 PM | ESPN+ | UC San Diego | Cal Poly | 17.5 | 25 | UC San Diego -17.5 |
| 7:30 PM | ESPN+ | Idaho | Sacramento State | 2.5 | 2 | Big Sky Rd 1 |
| 7:45 PM | CW | Pittsburgh | NC State | 6.5 | 7 | |
| 8 PM | ESPN2 | Little Rock | Morehead State | -4.5 | -6 | OVC FINALS |
| 8 PM | ACCN | Virginia | Georgia Tech | 8.5 | 11 | |
| 8:30 PM | Delaware | Hampton | 10.5 | 11 | CAA Rd 2 | |
| 8:30 PM | ESPN+ | James Madison | Marshall | 11.5 | 14 | Sun Belt QFs |
| 8:30 PM | ESPN+ | Western Carolina | Furman | -1.5 | 4 | SoCon QFs, Western Carolina -102 |
| 8:30 PM | FS1 | Seton Hall | DePaul | 22.5 | 22 | |
| 8:30 PM | SECN | LSU | Missouri | 7.5 | 10 | |
| 9 PM | BTN | Northwestern | Minnesota | 3.5 | 4 | |
| 9:30 PM | Kansas City | Denver | 4.5 | 3 | Summit QFs | |
| 10 PM | ESPN2 | Santa Clara | San Diego | 11.5 | 5 | West Coast QFs, San Diego +11.5 |
| 10 PM | ESPN+ | Northern Arizona | Idaho State | -5.5 | 1 | Big Sky Rd 1 – Northern Arizona +180 |
| 10:30 PM | CBSSN | Nevada | UNLV | 6.5 | 16 | Nevada -6.5 |
| 11 PM | FS1 | UCLA | Arizona State | 6.5 | 4 | |
| 12:30 AM | ESPN2 | San Francisco | Portland | 15.5 | 13 | West Coast QFs |