#ppiupsetalertrecord: 66-77 (.462)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11 AM | ESPN+ | Toledo | Kent State | 5.5 | 6 | MAC QFs |
| 11:30 AM | USA | Richmond | Saint Joseph’s | 3.5 | 5 | A10 QFs |
| 12 PM | FS1 | #2 Connecticut | Xavier | 14.5 | 15 | Big East QFs |
| 12 PM | ESPN | #4 North Carolina | Florida State | 10.5 | 13 | ACC QFs |
| 12 PM | BTN | Michigan State | Minnesota | 6.5 | 7 | Big Ten QFs |
| 12:30 PM | ESPN2 | #25 Texas Tech | #20 BYU | -2.5 | -2 | Big 12 QFs |
| 12:30 PM | ESPNU | East Carolina | Tulsa | 2.5 | -1 | AAC Rd 2, Tulsa +114 |
| 1 PM | SECN | LSU | Mississippi State | -4.5 | -7 | SEC Rd 2 |
| 1:30 PM | ESPN+ | Central Michigan | Bowling Green | -2.5 | -1 | MAC QFs |
| 2 PM | BTN | Wisconsin | Maryland | 3.5 | 6 | Big Ten Rd 2 |
| 2 PM | USA | Massachusetts | VCU | -1.5 | -4 | A10 QFs |
| 2:30 PM | FS1 | Seton Hall | St. John’s | -3.5 | -1 | Big East QFs, Seton Hall +150 |
| 2:30 PM | ESPNU | Memphis | Wichita State | 8.5 | 5 | AAC Rd 2 |
| 2:30 PM | ESPN2 | Pittsburgh | Wake Forest | -2.5 | 4 | ACC QFs, Pittsburgh +118 |
| 3 PM | ESPN | #1 Houston | TCU | 10.5 | 7 | Big 12 QFs, TCU +10.5 |
| 3 PM | PAC12 | #6 Arizona | USC | 8.5 | 14 | PAC 12 QFs, Arizona -8.5 |
| 3 PM | CBSSN | #18 Utah State | Fresno State | 12.5 | 18 | MW QFs, Utah State -12.5 |
| 3 PM | ESPN+ | Texas Southern | Jackson State | 2.5 | 3 | SWAC QFs |
| 3:30 PM | SECN | #15 South Carolina | Arkansas | 5.5 | 11 | SEC Rd 2, South Carolina -5.5 |
| 4 PM | ESPN+ | Akron | Miami (OH) | 8.5 | 9 | MAC QFs |
| 5 PM | USA | Loyola (CHI) | St. Bonaventure | 2.5 | 2 | A10 QFs |
| 5:30 PM | CBSSN | UNLV | San Diego State | -4.5 | -10 | MW QFs, San Diego State -4.5 |
| 5:30 PM | PAC12 | Oregon | UCLA | 2.5 | 2 | PAC 12 QFs |
| 6 PM | ESPN+ | Howard | Morgan State | 4.5 | 4 | MEAC QFs |
| 6:30 PM | BTN | Iowa | Ohio State | -1.5 | -2 | Big Ten Rd 2 |
| 6:30 PM | ESPN+ | Marist | Niagara | -1.5 | 3 | MAAC QFs, Marist -105 |
| 6:30 PM | ESPN+ | Ohio | Western Michigan | 9.5 | 9 | MAC QFs |
| 6:30 PM | ESPN+ | Liberty | UTEP | 4.5 | 2 | C-USA QFs |
| 7 PM | ESPN2 | #7 Iowa State | Kansas State | 7.5 | 6 | Big 12 QFs |
| 7 PM | FS1 | #8 Creighton | Providence | 8.5 | 8 | Big East QFs |
| 7 PM | ESPN | #11 Duke | NC State | 10.5 | 6 | ACC QFs,NC State +10.5 |
| 7 PM | ESPNU | North Texas | Tulane | 5.5 | 3 | AAC Rd 2, Tulane +5.5 |
| 7 PM | SECN | Texas A&M | Ole Miss | 4.5 | 1 | SEC Rd 2, Ole Miss +4.5 |
| 7:30 PM | USA | #24 Dayton | Duquesne | 6.5 | 3 | A10 QFs |
| 8 PM | ESPN+ | South Carolina State | Delaware State | 1.5 | 0 | MEAC QFs |
| 8:30 PM | BTN | Indiana | Penn State | -1.5 | 9 | Big Ten Rd 2, Indiana +106 |
| 9 PM | PAC12 | #22 Washington State | Stanford | 7.5 | 12 | PAC 12 QFs, Washington State -7.5 |
| 9 PM | CBSSN | #23 Nevada | Colorado State | 2.5 | 3 | MW QFs |
| 9 PM | ESPN+ | Rider | Saint Peter’s | -1.5 | 2 | MAAC QFs, Rider +100 |
| 9 PM | ESPN+ | Hawaii | CS Northridge | 5.5 | 8 | Big West QFs |
| 9 PM | ESPN+ | Seattle | California Baptist | 6.5 | 11 | WAC QFs, Seattle -6.5 |
| 9 PM | ESPN+ | Western Kentucky | New Mexico State | 5.5 | 11 | C-USA QFs, Western Kentucky -5.5 |
| 9 PM | ESPNU | SMU | Temple | 11.5 | 12 | AAC Rd 2 |
| 9:30 PM | FS1 | #10 Marquette | Villanova | 4.5 | 2 | Big East QFs |
| 9:30 PM | ESPN2 | #14 Baylor | Cincinnati | 6.5 | 9 | Big 12 QFs |
| 9:30 PM | ESPN+ | Southern University | Bethune-Cookman | 4.5 | 8 | SWAC QFs, Southern University -4.5 |
| 9:30 PM | SECN | Florida | Georgia | 7.5 | 12 | SEC Rd 2, Florida -7.5 |
| 9:30 PM | ESPN | Virginia | Boston College | 5.5 | 9 | ACC QFs, Virginia -5.5 |
| 11:30 PM | ESPN+ | Long Beach State | UC Riverside | 3.5 | 8 | Big West QFs, Long Beach St -3.5 |
| 11:30 PM | CBSSN | Boise State | New Mexico | -1.5 | 3 | MW QFs, New Mexico -108 |
| 11:30 PM | ESPN+ | UT-Arlington | Stephen F. Austin | 2.5 | 9 | WAC QFs, UT-Arlington -2.5 |