#ppiupsetalertrecord: 66-77 (.462)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12 PM | BTN | #3 Purdue | Michigan State | 7.5 | 11 | Big Ten QFs, Purdue -7.5 |
| 12:30 PM | CBSSN | Sam Houston State | UTEP | 4.5 | 5 | C-USA Semis |
| 1 PM | ESPN | #5 Tennessee | Mississippi State | 9.5 | 8 | SEC QFs |
| 1 PM | ESPN2 | South Florida | East Carolina | 7.5 | 10 | AAC QFs |
| 2:30 PM | BTN | Northwestern | Wisconsin | -4.5 | -4 | Big Ten QFs |
| 3 PM | ESPN+ | Grambling State | Bethune-Cookman | 2.5 | 3 | SWAC Semis |
| 3 PM | CBSSN | Western Kentucky | Middle Tennessee | 5.5 | 6 | C-USA Semis |
| 3 PM | ESPN2 | UAB | Wichita State | 4.5 | 5 | AAC QFs |
| 3:30 PM | ESPN | #12 Auburn | #15 South Carolina | 7.5 | 1 | SEC QFs, South Carolina +7.5 |
| 5 PM | CBSSN | Bowling Green | Kent State | -1.5 | 3 | MAC Semis, Bowling Green -110 |
| 5:30 PM | FOX | St. John’s | #2 Connecticut | -9.5 | -6 | Big East Semis, St. John’s +9.5 |
| 6 PM | ESPN+ | Norfolk State | Howard | 3.5 | 7 | MEAC Semis, Norfolk St -3.5 |
| 6:30 PM | BTN | #13 Illinois | Ohio State | 4.5 | 6 | Big Ten QFs |
| 6:30 PM | ESPNN | Quinnipiac | Saint Peter’s | 1.5 | 3 | MAAC Semis |
| 7 PM | ESPN+ | #1 Houston | #25 Texas Tech | 9.5 | 5 | Big 12 Semis, Texas Tech +9.5 |
| 7 PM | ESPN | #4 North Carolina | Pittsburgh | 7.5 | 8 | ACC QFs |
| 7 PM | SECN | #9 Kentucky | Texas A&M | 5.5 | 1 | SEC QFs, #ppiupsetalert, Texas A&M +184 |
| 7 PM | ESPNU | Florida Atlantic | North Texas | 5.5 | 7 | AAC QFs |
| 7:30 PM | CBSSN | Akron | Ohio | 2.5 | 3 | MAC Semis |
| 8 PM | PAC12 | #6 Arizona | Oregon | 11.5 | 13 | PAC 12 Semis |
| 8 PM | FS1 | #10 Marquette | Providence | 4.5 | 3 | Big East Semis |
| 8 PM | ESPN+ | North Carolina Central | Delaware State | 4.5 | 4 | MEAC Semis |
| 9 PM | BTN | Nebraska | indiana | 5.5 | 2 | Big Ten QFs, Indiana +5.5 |
| 9 PM | ESPNN | Fairfield | Marist | 5.5 | 4 | MAAC Semis |
| 9 PM | ESPN+ | UC Irvine | Long Beach State | 7.5 | 8 | Big West Semis |
| 9 PM | ESPN+ | Grand Canyon | Seattle | 5.5 | 7 | WAC Semis |
| 9 PM | ESPNU | Charlotte | Temple | 6.5 | 8 | AAC Semis |
| 9:30 PM | ESPN | #7 Iowa State | #14 Baylor | 1.5 | 1 | Big 12 Semis, #ppiupsetalert, Baylor -102 |
| 9:30 PM | #18 Utah State | San Diego State | 4.5 | 2 | MW Semis | |
| 9:30 PM | SECN | #19 Alabama | Florida | 4.5 | 0 | SEC QFs, #ppiupsetalert, Florida +158 |
| 9:30 PM | ESPN+ | Texas Southern | Alabama A&M | 6.5 | 7 | SWAC Semis |
| 9:30 PM | ESPN2 | Virginia | NC State | 2.5 | 4 | ACC Semis |
| 10:30 PM | FS1 | #22 Washington State | Colorado | -2.5 | 1 | PAC 12 Semis, #ppiupsetalert, Colorado -137 |
| 11:30 PM | ESPN2 | UC Davis | Hawaii | 1.5 | -1 | Big West Semis |
| 11:30 PM | ESPNU | Tarleton State | UT-Arlington | -1.5 | 2 | WAC Semis, Tarleton State -102 |
| 11:59 PM | New Mexico | Colorado State | 2.5 | -1 | MW Semis, Colorado State +125 |