#ppiupsetalert record: 34-52 (.395)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 6:40 PM | TruTV | #16 Prairie View A&M | #16 Lehigh | -2.5 | 0 | South Region – First Four, Prairie View +2.5 |
| 9:15 PM | TruTV | #11 Miami (OH) | #11 SMU | -7.5 | 2 | Midwest Region – First Four, Miami (OH) +245 |