#ppiupsetalert record: 39-58 (.402), #ncaavsspread: 17-19 (.472)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:10 PM | CBS | #1 Michigan | #9 Saint Louis | 12.5 | 8 | Midwest Rd 2 (Buffalo), Saint Louis +12.5 |
| 2:45 PM | CBS | #3 Michigan State | #6 Louisville | 4.5 | 5 | East Rd 2 (Buffalo), Michigan St -4.5 |
| 5:15 PM | CBS | #1 Duke | #9 TCU | 11.5 | 6 | East Rd 2 (Greenville), TCU +11.5 |
| 6:10 PM | TNT | #2 Houston | #10 Texas A&M | 10.5 | 8 | South Rd 2 (Oklahoma City), Texas A&M +10.5 |
| 7:10 PM | TruTV/TBS | #3 Gonzaga | #11 Texas | 6.5 | 7 | West Rd 2 (Portland), Gonzaga -6.5 |
| 7:50 PM | CBS | #3 Illinois | #11 VCU | 10.5 | 4 | South Rd 2 (Greenville), VCU +10.5 |
| 8:45 PM | TNT | #4 Nebraska | #5 Vanderbilt | -1.5 | -2 | South Rd 2 (Oklahoma City), #ppiupsetalert, Vanderbilt -130 |
| 9:45 PM | Tru/TV/TBS | #4 Arkansas | #12 High Point | 11.5 | 8 | West Rd 2 (Portland), High Point +11.5 |