#ppiposseofpicks: 123-155 (.442)
#ppiupsetalert: 34-45 (.430)
| Time | Chan | Home | Away | Spread | Margin | Alerts |
| 6:30 PM | FS1 | #19 Butler | #10 Villanova | 2.5 | 3 | #ppiupsetalert, Butler -130 |
| 7 PM | ESPN2 | #13 West Virginia | Iowa State | 11.5 | 14 | |
| 7 PM | BTN | Purdue | #17 Iowa | 3 | 0 | #ppiupsetalert, Purdue -155 |
| 7 PM | Providence | #21 Creighton | 1 | -4 | #ppiupsetalert, Creighton +104 | |
| 8:30 PM | FS1 | Georgetown | #12 Seton Hall | -3 | -3 | #ppiupsetalert, Georgetown +3 |
| 9 PM | ESPN2 | #5 Louisville | Wake Forest | 16 | 18 | |
| 9 PM | SECN | Vanderbilt | #18 LSU | -12 | -11 | |
| 7 PM | St. Bonaventure | George Washington | 9.5 | 11 | ||
| 7 PM | ESPN+ | Saint Louis | Duquesne | 4.5 | 7 | |
| 6:30 PM | ACCN | Notre Dame | Pittsburgh | 6 | 5 | |
| 7 PM | ACCNX | Virginia | Clemson | 8 | 7 | |
| 8:30 PM | ACCN | Miami (FL) | NC State | -3.5 | 2 | Miami (FL) +140 |
| 9 PM | ESPN2 | Louisville | Wake Forest | 16 | 18 | |
| 8 PM | CBSSN | Memphis | Temple | 8 | 10 | |
| 8 PM | ESPN+ | Oklahoma State | TCU | 3 | 1 | |
| 9 PM | BTN | Minnesota | Wisconsin | 3.5 | 3 | |
| 7 PM | ESPNU | Florida | Georgia | 9.5 | 8 | |
| 7 PM | SECN | Ole Miss | South Carolina | 1 | 1 |