#ppiupsetalert record: 32-49 (.395)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 11:30 AM | USA Net | Saint Louis | George Washington | 7.5 | 9 | A-10 QF (N) |
| 12 PM | BTN | #3 Michigan | Ohio State | 12.5 | 9 | Big Ten QF (N), Ohio St +12.5 |
| 12:30 PM | CBSSN | Louisiana Tech | Missouri State | 1.5 | 1 | CUSA Semis (N) |
| 1 PM | ESPN | #4 Florida | Kentucky | 11.5 | 8 | SEC QF (N), Kentucky +11.5 |
| 1 PM | ESPN2 | UAB | Charlotte | 5.5 | 6 | American QF (N) |
| 2 PM | ESPN+ | Alabama A&M | Prairie View A&M | 1.5 | 1 | SWAC Semis (N) |
| 2 PM | USA Net | Dayton | St. Bonaventure | 6.5 | 6 | A-10 QF (N) |
| 2:30 PM | BTN | #9 Illinois | #23 Wisconsin | 8.5 | 5 | Big Ten QF (N), Wisconsin +8.5 |
| 3 PM | CBSSN | Sam Houston State | Kennesaw State | 2.5 | 3 | CUSA Semis (N) |
| 3:30 PM | ESPN | #22 Vanderbilt | #25 Tennessee | -1.5 | 3 | SEC QF (N), Vanderbilt +102 |
| 3:30 PM | ESPN2 | Tulsa | North Texas | 8.5 | 7 | American QF (N) |
| 5 PM | CBSSN | Toledo | Massachusetts | 2.5 | 2 | MAC Semis (N) |
| 5 PM | USA Net | VCU | Duquesne | 8.5 | 8 | A-10 QF (N) |
| 5:30 PM | FOX | #13 St. John’s | Seton Hall | 7.5 | 8 | Big East Semis (N) |
| 6 PM | ESPN+ | Howard | South Carolina State | 15.5 | 10 | MEAC Semis (N), South Carolina St +15.5 |
| 6:30 PM | BTN | #11 Nebraska | #18 Purdue | -3.5 | -3 | Big Ten QF (N), #ppiupsetalert, Purdue -182 |
| 7 PM | ESPN | #2 Arizona | #7 Iowa State | 4.5 | 5 | Big 12 Semis (N) |
| 7 PM | ESPN2 | #10 Virginia | Miami (FL) | 3.5 | 4 | ACC Semis (N) |
| 7 PM | SECN | #15 Alabama | Ole Miss | 11.5 | 10 | SEC QF (N) |
| 7:30 PM | CBSSN | Akron | Kent State | 6.5 | 4 | MAC Semis (N) |
| 7:30 PM | CNBC | Saint Joseph’s | Davidson | 1.5 | 1 | A-10 QF (N) |
| 8 PM | FS1 | #6 Connecticut | Georgetown | 14.5 | 17 | Big East Semis (N) |
| 8 PM | ESPN+ | North Carolina Central | Delaware State | 3.5 | 5 | MEAC Semis (N) |
| 8:30 PM | ESPN+ | Florida A&M | Southern University | -3.5 | 0 | SWAC Semis (N), Florida A&M +3.5 |
| 9 PM | BTN | #8 Michigan State | UCLA | 5.5 | 4 | Big Ten QF (N) |
| 9 PM | ESPN+ | Utah Valley | UT-Arlington | 9.5 | 7 | WAC Semis (N) |
| 9 PM | ESPNU | UC Irvine | Cal State Northridge | 4.5 | 4 | Big West Semis (N) |
| 9:30 PM | ESPN2 | #1 Duke | Clemson | 10.5 | 6 | ACC Semis (N), Clemson +10.5 |
| 9:30 PM | ESPN | #5 Houston | #14 Kansas | 5.5 | 3 | Big 12 Semis (N) |
| 9:30 PM | SECN | #17 Arkansas | Oklahoma | 7.5 | 4 | SEC QF (N), Oklahoma +7.5 |
| 9:30 PM | CBSSN | Utah State | Nevada | 6.5 | 6 | MW Semis (N) |
| 11:30 PM | ESPN+ | California Baptist | Utah Tech | 7.5 | 4 | WAC Semis (N), Utah Tech +7.5 |
| 11:30 PM | ESPN2 | Hawaii | Cal State Fullerton | 4.5 | 1 | Big West Semis (N), Cal State Fullerton +4.5 |
| 11:59 PM | CBSSN | San Diego State | New Mexico | 2.5 | 0 | MW Semis (N) |