#ppiupsetalertrecord: 75-81 (.481)
| Time | Chan | Home | Away | Spread | Expected | Alerts |
| 12:10 PM | CBS | #2 Marquette | #10 Colorado | 4.5 | 1 | South Rd 2 (Indianapolis), #ppiupsetalert, Colorado +4.5 |
| 2:40 PM | CBS | #1 Purdue | #8 Utah State | 11.5 | 6 | Midwest Rd 2 (Indianapolis), Utah State +11.5 |
| 5:15 PM | CBS | #4 Duke | #12 James Madison | 7.5 | 2 | South Rd 2 (Brooklyn), #ppiupsetalert, James Madison +7.5 |
| 6:10 PM | TNT | #3 Baylor | #6 Clemson | 4.5 | -4 | West Rd 2 (Memphis), #ppiupsetalert, Clemson +146 |
| 7:10 PM | TBS | #4 Alabama | #12 Grand Canyon | 6.5 | 0 | West Rd 2 (Spokane), #ppiupsetalert, Grand Canyon +6.5 |
| 7:45 PM | TruTV | #1 Connecticut | #9 Northwestern | 13.5 | 17 | East Rd 2 (Brooklyn), Connecticut -13.5 |
| 8:40 PM | TNT | #1 Houston | #9 Texas A&M | 9.5 | 8 | South Rd 2 (Memphis) |
| 9:40 PM | TBS | #5 San Diego State | #13 Yale | 5.5 | 7 | East Rd 2 (Spokane) |